Classics in Chemical Neuroscience: Chlorpromazine.,ACS Chemical Neuroscience

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Classics in Chemical Neuroscience: Chlorpromazine.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-07-16 , DOI: 10.1021/acschemneuro.8b00258
Debra Boyd-Kimball ₁ , Katelyn Gonczy ₁ , Benjamin Lewis ₁ , Thomas Mason ₁ , Nicole Siliko ₁ , Jacob Wolfe ₁

Affiliation

The discovery of chlorpromazine in the early 1950s revolutionized the clinical treatment of schizophrenia, galvanized the development of psychopharmacology, and standardized protocols used for testing the clinical efficacy of antipsychotics. Furthermore, chlorpromazine expanded our understanding of the role of chemical messaging in neurotransmission and reduced the stigma associated with mental illness, facilitating deinstitutionalization in the 1960s and 1970s. In this review, we will discuss the synthesis, manufacturing, metabolism and pharmacokinetics, pharmacology, structure-activity relationship, and adverse effects of chlorpromazine. In conclusion, we summarize the history and significant contributions of chlorpromazine that have resulted in this potent first-generation antipsychotic maintaining its clinical relevance for nearly 70 years.

中文翻译：

化学神经科学经典著作：氯丙嗪。

1950年代初发现氯丙嗪彻底改变了精神分裂症的临床治疗方法，刺激了心理药理学的发展，并标准化了用于测试抗精神病药临床疗效的方案。此外，氯丙嗪扩大了我们对化学信息在神经传递中的作用的理解，并减少了与精神疾病相关的污名，促进了1960年代和1970年代的去机构化。在这篇综述中，我们将讨论氯丙嗪的合成，制造，代谢和药代动力学，药理学，结构-活性关系以及不良反应。总之，我们总结了氯丙嗪的历史和重大贡献，这些物质导致这种有效的第一代抗精神病药在临床上保持了近70年的历史。

更新日期：2018-06-21

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