Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In this review we summarize the evidence in the literature, to consolidate the current knowledge on the dysregulation of zinc homeostasis in CVDs, and to explore the significant roles of the zinc homeostasis-regulatory proteins in cardiac physiology and pathophysiology. Moreover, this review also deliberates on the potential diagnostic and prognostic implications of zinc/zinc homeostasis-associated molecules (ZIP, ZnT, and MTs) in CVDs.

中文翻译：

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锌缺乏和细胞氧化应激：在心血管疾病中的预后意义。

锌是人类健康的必需营养素，具有抗氧化应激和抗发炎的功能。锌缺乏与心血管疾病（CVD）的发展之间的关联得到了许多研究的支持。补充锌可以降低动脉粥样硬化的风险，并防止心肌梗塞和缺血/再灌注损伤。在这篇综述中，我们总结了文献中的证据，以巩固有关CVD中锌稳态平衡失调的当前知识，并探讨锌稳态平衡调节蛋白在心脏生理和病理生理中的重要作用。此外，本综述还探讨了CVD中锌/锌稳态相关分子（ZIP，ZnT和MTs）的潜在诊断和预后意义。