Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity,Chemistry of Materials

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Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1021/acs.chemmater.8b01272
Jianmin Xue _{1,

2} , Chun Feng _{1,

2} , Lunguo Xia ₃ , Dong Zhai ₁ , Bing Ma ₁ , Xiaocheng Wang _{1,

2} , Bing Fang ₃ , Jiang Chang ₁ , Chengtie Wu ₁

Affiliation

The creation of a bone substitute with both excellent mechanical strength and bioactivity is still a challenge in bone tissue engineering biomaterials. To this end, inspired by the microstructure of nacre, multilayered graphene oxide/chitosan/calcium silicate (GO/CTS/CS) biomaterials were successfully prepared via a bottom-up assembly approach. The GO/CTS/CS biomaterials emulated the “brick and mortar” layered microstructure via chemical assembly and the multilayered helical cylinder macrostructure. In addition, benefiting from the interface interactions in the layered microstructure as well as the multilayered helical cylinder macrostructure, the GO/CTS/CS biomaterials possessed high flexural strength (137.2 MPa), compressive strength (80.2 MPa), toughness (1.46 MJ/m³), and specific strength (124.7 MPa Mg^–1 m^–3), which are close to those of cortical bone. Furthermore, because of the bioactive chemical components of GO and CS, the multilayered GO/CTS/CS biomaterials significantly improved osteogenesis and angiogenesis in vitro. Moreover, the multilayered GO/CTS/CS biomaterials showed enhanced in vivo bone-forming ability due to the contributions of bioactive chemical components and the multilayered helical cylinder macrostructure. This work not only provides a biomaterial with excellent mechanical strength and bioactivity but also offers a strategy for fabrication of high-performance biomaterials based on bioinspired chemistry and engineering.

中文翻译：

具有高机械强度和成骨活性的多层生物材料的组装制备

具有优异的机械强度和生物活性的骨替代物的产生仍然是骨组织工程生物材料中的挑战。为此，受珍珠层微结构的启发，通过自下而上的组装方法成功地制备了多层氧化石墨烯/壳聚糖/硅酸钙（GO / CTS / CS）生物材料。GO / CTS / CS生物材料通过化学组装和多层螺旋圆柱体宏观结构模拟了“砖和灰浆”分层的微观结构。此外，GO / CTS / CS生物材料得益于分层微观结构以及多层螺旋圆柱体宏观结构中的界面相互作用，具有较高的抗弯强度（137.2 MPa），抗压强度（80.2 MPa），韧性（1.46 MJ / m）³）和比强度（124.7 MPa Mg^–1 m ^–3），其接近皮质骨。此外，由于GO和CS的生物活性化学成分，多层GO / CTS / CS生物材料在体外显着改善了成骨和血管生成。此外，由于生物活性化学成分和多层螺旋圆柱体宏观结构的贡献，多层GO / CTS / CS生物材料显示出增强的体内成骨能力。这项工作不仅为生物材料提供了优异的机械强度和生物活性，而且为基于生物启发化学和工程技术制造高性能生物材料提供了策略。

更新日期：2018-06-21

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