Mechanobiology of Tumor Growth,Chemical Reviews

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Mechanobiology of Tumor Growth
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1021/acs.chemrev.8b00042
Parthiv Kant Chaudhuri _{1,

2} , Boon Chuan Low _{1,

3,

4} , Chwee Teck Lim _{1,

5,

6}

Affiliation

Over the past decade, researchers have highlighted the importance of mechanical cues of the metastatic niche such as matrix stiffness, topography, mechanical stresses, and deformation on cells in influencing tumor growth and proliferation. Understanding the cellular and molecular basis and fine-tuning the mechano-response of cancer cells to this niche could lead to new and novel therapeutic interventions. In this review, we discuss the importance of mechanical cues surrounding tumor microenvironment that govern the growth and progression of cancer. We also highlight some emergent principles underlying the mechanosensing and mechanotransduction mechanisms that link cellular responses such as gene expression to phenotypic changes arising from such external cues. Recent technological advancements to visualize, quantify, model, and test these crucial steps with great precision will further advance our understanding of this phenomenon. We will conclude by showcasing potential applications of mechanobiology in controlling cancer growth as alternative cancer treatment regimes.

中文翻译：

肿瘤生长的力学生物学

在过去的十年中，研究人员强调了转移性利基的机械提示在影响肿瘤生长和增殖中的重要性，例如基质刚度，形貌，机械应力和细胞变形。了解细胞和分子基础，并调整癌细胞对这种利基的机械反应可能会导致新的和新颖的治疗干预。在这篇综述中，我们讨论了控制肿瘤生长和发展的肿瘤微环境周围机械提示的重要性。我们还强调了一些机械感应和机械转导机制的新兴原理，这些机制将诸如基因表达之类的细胞反应与由这种外部线索引起的表型变化联系起来。可视化，量化，建模，并以高精度测试这些关键步骤将进一步增进我们对这一现象的理解。我们将通过展示机械生物学在控制癌症生长方面的潜在应用作为替代性癌症治疗方案来得出结论。

更新日期：2018-06-21

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