Multivalent Ligands: Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin‐Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration (Adv. Healthcare Mater. 12/2018),Advanced Healthcare Materials

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Multivalent Ligands: Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin‐Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration (Adv. Healthcare Mater. 12/2018)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-06-20 , DOI: 10.1002/adhm.201870048
Fatemeh Karimi _{1,

2} , Andrea J. O'Connor ₁ , Greg G. Qiao ₂ , Daniel E. Heath ₁

Affiliation

Biomaterials functionalized with nano‐scale clusters of integrin‐binding ligands exhibit enhanced cell‐material interactions including higher adhesion rates, greater adhesion strength, increased proliferation, and better biomedical device integration in comparison to materials functionalized with randomly spaced ligands. The review in article 1701324 by Daniel E. Heath, Greg G. Qiao, and co‐workers focuses on the methodologies that have been developed in order to generate these materials as well as their improved in vitro and in vivo performance.

中文翻译：

多价配体：整联蛋白聚簇的问题：用多价整联蛋白结合的配体功能化以改善细胞粘附，迁移，分化，血管生成和生物医学设备整合的生物材料的综述（Adv。Healthcare Mater.12 / 2018）

与用随机间隔的配体进行功能化的材料相比，用整联蛋白结合性配体的纳米级簇进行功能化的生物材料具有增强的细胞材料相互作用，包括更高的粘附率，更大的粘附强度，增强的增殖以及更好的生物医学装置集成。Daniel E. Heath，Greg G. Qiao及其同事在文章1701324中进行的审查重点在于为生成这些材料以及改进的体外和体内性能而开发的方法。

更新日期：2018-06-20

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