What Has Come out from Phytomedicines and Herbal Edibles for the Treatment of Cancer?,ChemMedChem

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What Has Come out from Phytomedicines and Herbal Edibles for the Treatment of Cancer?
ChemMedChem ( IF 3.6 ) Pub Date : 2018-09-05 , DOI: 10.1002/cmdc.201800343
Srinivasa Reddy Bonam _{1,

2,

3} , Yuan Seng Wu ₄ , Lakshmi Tunki ₂ , Ranjithkumar Chellian ₄ , Mahabalarao Sampath Kumar Halmuthur _{2,

3} , Sylviane Muller _{1,

5} , Vijayapandi Pandy _{4,

6}

Affiliation

Several modern treatment strategies have been adopted to combat cancer with the aim of minimizing toxicity. Medicinal plant‐based compounds with the potential to treat cancer have been widely studied in preclinical research and have elicited many innovations in cutting‐edge clinical research. In parallel, researchers have eagerly tried to decrease the toxicity of current chemotherapeutic agents either by combining them with herbals or in using herbals alone. The aim of this article is to present an update of medicinal plants and their bioactive compounds, or mere changes in the bioactive compounds, along with herbal edibles, which display efficacy against diverse cancer cells and in anticancer therapy. It describes the basic mechanism(s) of action of phytochemicals used either alone or in combination therapy with other phytochemicals or herbal edibles. This review also highlights the remarkable synergistic effects that arise between certain herbals and chemotherapeutic agents used in oncology. The anticancer phytochemicals used in clinical research are also described; furthermore, we discuss our own experience related to semisynthetic derivatives, which are developed based on phytochemicals. Overall, this compilation is intended to facilitate research and development projects on phytopharmaceuticals for successful anticancer drug discovery.

中文翻译：

植物药和草药可食物对癌症的治疗作用是什么？

为了使毒性最小化，已经采用了几种现代治疗策略来对抗癌症。在临床前研究中已经广泛研究了具有治疗癌症潜力的药用植物基化合物，并在前沿临床研究中引发了许多创新。同时，研究人员急切地试图通过将它们与草药合用或单独使用草药来降低当前化学治疗剂的毒性。本文的目的是介绍药用植物及其生物活性化合物的更新，或者仅是生物活性化合物的变化，以及草药食品，这些食品对多种癌细胞和抗癌治疗均显示出功效。它描述了单独使用或与其他植物化学药品或草药食品配合使用的植物化学药品的基本作用机理。这篇综述还强调了某些草药与肿瘤学中使用的化学治疗剂之间产生的显着协同作用。还描述了用于临床研究的抗癌植物化学物质。此外，我们讨论了我们与基于植物化学物质开发的半合成衍生物相关的经验。总体而言，该汇编旨在促进有关成功开发抗癌药物的植物药研发项目。还描述了用于临床研究的抗癌植物化学物质。此外，我们讨论了我们与基于植物化学物质开发的半合成衍生物相关的经验。总体而言，该汇编旨在促进有关成功开发抗癌药物的植物药研发项目。还描述了用于临床研究的抗癌植物化学物质。此外，我们讨论了我们与基于植物化学物质开发的半合成衍生物相关的经验。总体而言，该汇编旨在促进有关成功开发抗癌药物的植物药研发项目。

更新日期：2018-09-05

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