Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder. Indeed, some nutrients can protect all kind of cells, including neurons. As prevention is better than cure, life style improvement, with a special emphasis on diet, should seriously be considered as an anti-AD track and intake of nutrients promoting neuronal health is the need of the hour. Diets rich in unsaturated fatty acids, polyphenols and vitamins have been shown to protect against AD, whereas saturated fatty acids-containing diets deprived of polyphenols promote the development of the disease. Thus, Mediterranean diets, mainly composed of fruits, vegetables and omega-3 fatty acids, stand as valuable, mild and preventive anti-AD agents. This review focuses on our current knowledge in the field and how one can fight this devastating neurodegenerative disorder through the simple proper modification of our life style.

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神经营养素作为抗老年痴呆症的药物：一项重要的评论

阿尔茨海默氏病（AD）的特征是大量神经元死亡，导致记忆力丧失，认知障碍和行为改变，最终导致痴呆症和死亡。AD是由分子事件如氧化应激，蛋白质聚集，线粒体功能障碍和神经炎症控制的多因素病理学。如今，尚无有效的改善AD疾病的治疗方法，流行病学研究表明饮食和营养对这种疾病的发展有重要影响。确实，某些营养素可以保护所有种类的细胞，包括神经元。由于预防胜于治疗，因此改善生活方式（特别是饮食）应被视为一种抗AD途径，而摄入促进神经元健康的营养物质则是当下的需要。富含不饱和脂肪酸，多酚和维生素的饮食已被证明可预防AD，而不含多酚的含饱和脂肪酸的饮食则可促进该疾病的发展。因此，主要由水果，蔬菜和omega-3脂肪酸组成的地中海饮食是有价值，温和和预防性的抗AD药物。这篇综述着重于我们在该领域的当前知识以及如何通过简单地适当地改变我们的生活方式来对抗这种毁灭性的神经退行性疾病。轻度和预防性抗AD药物。这篇综述着重于我们目前在该领域的知识，以及如何通过简单地适当改变我们的生活方式来应对这种毁灭性的神经退行性疾病。轻度和预防性抗AD药物。这篇综述着重于我们在该领域的当前知识以及如何通过简单地适当地改变我们的生活方式来对抗这种毁灭性的神经退行性疾病。