Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1146/annurev-biochem-062917-012405 Wei Yang 1 , Yang Gao 1
The number of DNA polymerases identified in each organism has mushroomed in the past two decades. Most newly found DNA polymerases specialize in translesion synthesis and DNA repair instead of replication. Although intrinsic error rates are higher for translesion and repair polymerases than for replicative polymerases, the specialized polymerases increase genome stability and reduce tumorigenesis. Reflecting the numerous types of DNA lesions and variations of broken DNA ends, translesion and repair polymerases differ in structure, mechanism, and function. Here, we review the unique and general features of polymerases specialized in lesion bypass, as well as in gap-filling and end-joining synthesis.
中文翻译:
转运和修复DNA聚合酶:多样的结构和机制。
在过去的二十年中,每个生物体中鉴定出的DNA聚合酶数量迅速增加。大多数新发现的DNA聚合酶专门从事跨病变的合成和DNA修复,而不是复制。尽管与转染和修复聚合酶相比,转移和修复聚合酶的固有错误率更高,但是专门的聚合酶可提高基因组稳定性并减少肿瘤发生。反映多种类型的DNA损伤和DNA末端断裂的变化,跨损伤和修复聚合酶的结构,机制和功能各不相同。在这里,我们回顾了专门用于病变旁路以及间隙填充和末端连接合成的聚合酶的独特和一般特征。