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Reductionist Approach in Peptide-Based Nanotechnology
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1146/annurev-biochem-062917-012541
Ehud Gazit 1
Affiliation  

The formation of ordered nanostructures by molecular self-assembly of proteins and peptides represents one of the principal directions in nanotechnology. Indeed, polyamides provide superior features as materials with diverse physical properties. A reductionist approach allowed the identification of extremely short peptide sequences, as short as dipeptides, which could form well-ordered amyloid-like β-sheet-rich assemblies comparable to supramolecular structures made of much larger proteins. Some of the peptide assemblies show remarkable mechanical, optical, and electrical characteristics. Another direction of reductionism utilized a natural noncoded amino acid, α-aminoisobutryic acid, to form short superhelical assemblies. The use of this exceptional helix inducer motif allowed the fabrication of single heptad repeats used in various biointerfaces, including their use as surfactants and DNA-binding agents. Two additional directions of the reductionist approach include the use of peptide nucleic acids (PNAs) and coassembly techniques. The diversified accomplishments of the reductionist approach, as well as the exciting future advances it bears, are discussed.

中文翻译:


基于肽的纳米技术的还原论方法

通过蛋白质和肽的分子自组装形成有序纳米结构代表了纳米技术的主要方向之一。事实上,聚酰胺作为具有多种物理特性的材料提供了卓越的特性。还原论方法可以识别极短的肽序列,如二肽一样短,它们可以形成有序的富含淀粉样蛋白样β-折叠的组装体,与由更大的蛋白质制成的超分子结构相当。一些肽组装体表现出显着的机械、光学和电学特性。还原论的另一个方向是利用天然非编码氨基酸α-氨基异丁酸来形成短的超螺旋组装体。使用这种特殊的螺旋诱导基序可以制造用于各种生物界面的单个七肽重复序列,包括它们作为表面活性剂和 DNA 结合剂的用途。还原论方法的另外两个方向包括使用肽核酸(PNA)和共组装技术。讨论了还原论方法的多样化成就,以及它所带来的令人兴奋的未来进展。

更新日期:2018-06-20
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