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Regulation of Clathrin-Mediated Endocytosis
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1146/annurev-biochem-062917-012644
Marcel Mettlen 1 , Ping-Hung Chen 1 , Saipraveen Srinivasan 1 , Gaudenz Danuser 1, 2 , Sandra L. Schmid 1
Affiliation  

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for regulating cell surface signaling. CME occurs via the assembly and maturation of clathrin-coated pits that concentrate cargo as they invaginate and pinch off to form clathrin-coated vesicles. In addition to the major coat proteins, clathrin triskelia and adaptor protein complexes, CME requires a myriad of endocytic accessory proteins and phosphatidylinositol lipids. CME is regulated at multiple steps—initiation, cargo selection, maturation, and fission—and is monitored by an endocytic checkpoint that induces disassembly of defective pits. Regulation occurs via posttranslational modifications, allosteric conformational changes, and isoform and splice-variant differences among components of the CME machinery, including the GTPase dynamin. This review summarizes recent findings on the regulation of CME and the evolution of this complex process.

中文翻译:


网格蛋白介导的内吞作用的调节

网格蛋白介导的内吞作用(CME)是哺乳动物细胞中的主要内吞途径。它负责跨膜受体和转运蛋白的吸收,响应环境变化重塑质膜组成,并调节细胞表面信号传导。CME是通过包被网格蛋白的小窝的组装和成熟而发生的,这些小窝在货物侵入和挤压时会浓缩货物,从而形成包被网格蛋白的小泡。除了主要的外壳蛋白,网格蛋白三叶草和衔接子蛋白复合物外,CME还需要大量的内吞辅助蛋白和磷脂酰肌醇脂质。CME在多个步骤中受到监管-初始,货物选择,成熟和裂变-并由内吞检查点进行监控,该检查点会导致缺陷坑的拆卸。调节是通过翻译后修饰进行的,变构构象变化,以及CME机械组件(包括GTPase dynamin)之间的同工型和剪接变体差异。这篇综述总结了有关CME调控和此复杂过程演变的最新发现。

更新日期:2018-06-20
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