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New biological activity of the polysaccharide fraction from Cantharellus cibarius and its structural characterization
Food Chemistry ( IF 8.5 ) Pub Date : 2018-06-21 , DOI: 10.1016/j.foodchem.2018.06.106
Natalia Nowacka-Jechalke , Renata Nowak , Marek Juda , Anna Malm , Marta Lemieszek , Wojciech Rzeski , Zbigniew Kaczyński

One of the most commonly consumed mushrooms in Europe is Cantharellus cibarius, also known as chanterelles. Therefore, the investigation of the pro-health properties of crude polysaccharides from this species was performed. The obtained results indicate that the polysaccharide fraction from C. cibarius inhibits the activity of both COX-1 and COX-2. Moreover, the prebiotic potential was revealed in relation to Lactobacillus strains. Crude polysaccharides were found to inhibit the proliferation of colon cancer cells with the simultaneous absence of toxicity towards normal cells. The purification and structural characterization of the examined polysaccharide fraction from C. cibarius indicates that it consists of one monosaccharide in the repeating unit →6)-α-D-Manp-(1→. The presented activities indicate for the first time that this edible mushroom possesses interesting chemopreventive potential, especially against colon cancer.



中文翻译:

鸡油菌Cantharellus cibarius)多糖级分的新生物活性及其结构表征

欧洲最常用的蘑菇之一是Cantharellus cibarius,也被称为蘑菇。因此,对来自该物种的粗多糖的促健康特性进行了研究。获得的结果表明,来自C.cibarius的多糖级分抑制了COX-1和COX-2的活性。此外,与乳酸菌菌株有关的益生元潜力被揭示。发现粗多糖抑制结肠癌细胞的增殖,同时对正常细胞没有毒性。检验的C. cibarius多糖组分的纯化和结构表征 表示其在重复单元→6)-α-D-Manp-(1→)中由一个单糖组成,所提出的活性首次表明该食用菌具有令人感兴趣的化学预防潜力,尤其是对结肠癌的预防作用。

更新日期:2018-06-21
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