Online monitoring of end-tidal propofol provides important information of anesthesia deepness for anesthetists as propofol concentrations in plasma and breath are well correlated. In this work, a dopant-assisted photoionization positive ion mobility spectrometry (DAPI-PIMS) coupled with time-resolved purge introduction was developed for online quantitative monitoring end-tidal propofol. With optimized dopant, toluene, the selectivity and sensitivity of propofol was improved as interference from sevoflurane was eliminated. Using the time-resolved purge introduction, the response of propofol and moisture was separated due to their absorption differences on the inwall of the fluorinated ethylene propylene (FEP) sample loop, ensuring sensitive measurement of end-tidal propofol with a short response time of 4 s. The quantitative equation derived from the second order reaction kinetics model extended the quantitative range of propofol from 0.2 ppbv to 45 ppbv. Finally, the method was used to monitor the intraoperative end-tidal propofol of six patients, and the results nicely demonstrated its feasibility in practical clinical environment.

中文翻译：

---

掺杂剂辅助光电离正离子迁移谱与时间分辨清除引入相结合，用于术中呼气末丙泊酚的在线定量监测

呼气末丙泊酚的在线监测为麻醉师提供了重要的麻醉深度信息，因为血浆和呼吸中的丙泊酚浓度具有良好的相关性。在这项工作中，开发了一种掺杂剂辅助光电离正离子迁移谱 (DAPI-PIMS) 与时间分辨吹扫引入相结合，用于在线定量监测呼气末丙泊酚。使用优化的掺杂剂甲苯，由于消除了七氟醚的干扰，丙泊酚的选择性和灵敏度得到了提高。使用时间分辨吹扫引入，丙泊酚和水分的响应由于它们在氟化乙烯丙烯 (FEP) 样品定量环内壁上的吸收差异而被分离，确保以 4 的短响应时间对呼气末丙泊酚进行灵敏测量s。源自二级反应动力学模型的定量方程将丙泊酚的定量范围从 0.2 ppbv 扩展到 45 ppbv。最后，将该方法用于6例患者术中呼气末丙泊酚的监测，结果很好地证明了其在实际临床环境中的可行性。