Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders,ACS Omega

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Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders
ACS Omega ( IF 3.7 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1021/acsomega.8b00966
Zhenyu Shi ₁ , Gerald B. Hammond ₂ , Bo Xu _{1,

2}

Affiliation

We have developed a substantially faster and greener technique for routine chemical reaction workups. We use silicone elastomer-coated glass powder (“FastWoRX”) as an absorbent to extract organic products from a quenched aqueous reaction mixture. After filtration, FastWoRX powder loaded with organic products can serve as a convenient input for flash chromatographic separations. With this technique, tedious and solvent-consuming liquid–liquid extractions are replaced by a simple filtration. Use of FastWoRX reduces solvent use and the E-factor by up to an order of magnitude compared to traditional liquid–liquid extraction-based workup.

中文翻译：

使用有机硅弹性体涂覆的玻璃粉可以更快，更环保地进行化学反应后处理

我们已经为常规化学反应后处理开发了一种更快，更环保的技术。我们使用有机硅弹性体涂层玻璃粉（“ FastWoRX”）作为吸收剂，从淬灭的水性反应混合物中提取有机产物。过滤后，装有有机产品的FastWoRX粉末可作为快速色谱分离的便捷输入。使用这种技术，简单的过滤代替了乏味且消耗溶剂的液-液萃取。与传统的基于液-液萃取的后处理相比，FastWoRX的使用最多可减少溶剂使用量和E因子。

更新日期：2018-06-21

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