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Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1039/c8tb00883c Mengliang Zhu 1, 2, 3, 4, 5 , Peipei Xing 1, 2, 3, 4, 5 , Yabin Zhou 3, 4, 5, 6 , Lei Gong 1, 2, 3, 4, 5 , Jinghui Zhang 1, 2, 3, 4, 5 , Dongdong Qi 1, 2, 3, 4, 5 , Yongzhong Bian 1, 2, 3, 4, 5 , Hongwu Du 3, 4, 5, 6 , Jianzhuang Jiang 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1039/c8tb00883c Mengliang Zhu 1, 2, 3, 4, 5 , Peipei Xing 1, 2, 3, 4, 5 , Yabin Zhou 3, 4, 5, 6 , Lei Gong 1, 2, 3, 4, 5 , Jinghui Zhang 1, 2, 3, 4, 5 , Dongdong Qi 1, 2, 3, 4, 5 , Yongzhong Bian 1, 2, 3, 4, 5 , Hongwu Du 3, 4, 5, 6 , Jianzhuang Jiang 1, 2, 3, 4, 5
Affiliation
BODIPY-based probes were developed for the ratiometric fluorescence detection of pH values. They showed high sensitivity under acidic conditions via a protonation-modulated ICT mechanism and could selectively stain lysosomes, and thus could be applied for imaging and detecting abnormal pH decreases in live cells.
中文翻译:
基于长波长BODIPY的溶酶体靶向比例荧光pH探针†
开发了基于BODIPY的探针,用于pH值的比例荧光检测。它们在酸性条件下通过质子调节的ICT机理显示出很高的灵敏度,并且可以选择性地对溶酶体染色,因此可以用于成像和检测活细胞中pH的异常降低。
更新日期:2018-06-21
中文翻译:
基于长波长BODIPY的溶酶体靶向比例荧光pH探针†
开发了基于BODIPY的探针,用于pH值的比例荧光检测。它们在酸性条件下通过质子调节的ICT机理显示出很高的灵敏度,并且可以选择性地对溶酶体染色,因此可以用于成像和检测活细胞中pH的异常降低。