Meta‐Selective C–H Alkylation of 2‐Phenylpyridine Catalyzed by Ruthenium: DFT Study on the Mechanism and Regioselectivity,European Journal of Organic Chemistry

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Meta‐Selective C–H Alkylation of 2‐Phenylpyridine Catalyzed by Ruthenium: DFT Study on the Mechanism and Regioselectivity
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-20 , DOI: 10.1002/ejoc.201800772
Lei Zhang ₁ , Lu Yu ₁ , Jianguo Zhou ₁ , Yu Chen _{1,

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Affiliation

The meta‐selective C–H alkylation of 2‐phenylpyridine catalyzed by ruthenium was studied by using DFT calculations. The competition between electrophilic and radical mechanisms is determined by the nature of the alkylating reagents. The regioselectivity issue was addressed in detail.