A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine,Angewandte Chemie International Edition

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A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-06-21 , DOI: 10.1002/anie.201806821
Alexander Lipp ₁ , Dorota Ferenc ₁ , Christoph Gütz ₁ , Mario Geffe ₁ , Nina Vierengel ₁ , Dieter Schollmeyer ₁ , Hans J. Schäfer ₂ , Siegfried R. Waldvogel ₁ , Till Opatz ₁

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Enforcement of selectivity through a combination of electrochemistry and substrate design enabled the biomimetic synthesis of the economically important opium alkaloid (–)‐thebaine. In their Communication (DOI: 10.1002/anie.201803887) T. Opatz and co‐workers present a regio‐ and diastereoselective anodic coupling of 3’,4’,5’‐trioxygenated laudanosine derivatives, thereby helping to overcome a long‐standing electrosynthetic challenge. Graphic edited by L. Großmann (Mainz).

中文翻译：

（-）-蒂巴因仿生全合成中的区域和非对映选择性阳极芳基-芳基偶联

通过将电化学和底物设计相结合来增强选择性，从而可以仿生合成经济上重要的鸦片生物碱（–）–蒂巴因。T.Opatz和同事在他们的交流中（DOI：10.1002 / anie.201803887）介绍了3'，4'，5'-三加氧月桂肌苷衍生物的区域和非对映选择性阳极偶联，从而有助于克服长期存在的电合成挑战。图片由L.Großmann（美因茨）编辑。

更新日期：2018-06-22

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