A novel 6-quinoxalinamine-based fluorescent probe for real-time detection of palladium(ii) ions in pure water and bio-imaging†,New Journal of Chemistry

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A novel 6-quinoxalinamine-based fluorescent probe for real-time detection of palladium(ii) ions in pure water and bio-imaging†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-06-22 00:00:00 , DOI: 10.1039/c8nj01614c
Chuanliang Che _{1,

2,

3,

4} , Xiangzhu Chen _{1,

2,

3,

4} , Hongmei Wang _{1,

2,

3,

4} , Jia-Qi Li _{1,

2,

3,

4} , Yumei Xiao _{1,

2,

3,

4} , Bin Fu _{1,

2,

3,

4} , Zhaohai Qin _{1,

2,

3,

4}

Affiliation

A novel quinoxalinamine-containing fluorescent probe (LK) was designed and synthesized based on coordination for real-time detection of Pd²⁺. LK was easily obtained in high yield by the Suzuki cross-coupling reaction. The quinoxaline group provides the sensor LK with good water-solubility, which is important for monitoring in biological systems. The probe possessed large Stokes shifts and excellent selectivity for detecting Pd²⁺ in the presence of various potential interfering metal ions. The detection limit (22 nM) was far lower than the criterion of the World Health Organization in drinking water. Moreover, LK displayed high sensitivity for identification of Pd²⁺ in real water samples. More importantly, the sensor LK succeeded in imaging detection of Pd²⁺ in live cells with good membrane permeability and low toxicity.

中文翻译：

一种基于6-喹喔啉胺的新型荧光探针，可实时检测纯水中的钯（ii）离子并进行生物成像†

设计并合成了一种新型的含喹喔啉胺的荧光探针（LK），用于实时检测Pd ²⁺。通过铃木交叉偶联反应容易以高收率获得LK。喹喔啉组为传感器LK提供了良好的水溶性，这对于监测生物系统非常重要。该探针具有大的斯托克斯位移和出色的选择性，可在存在各种潜在干扰金属离子的情况下检测Pd ²⁺。饮用水中的检出限（22 nM）远低于世界卫生组织的标准。此外，LK对Pd ^2+的识别具有很高的灵敏度在真实的水样中。更重要的是，传感器LK成功地对具有良好膜渗透性和低毒性的活细胞中的Pd ²⁺进行了成像检测。

更新日期：2018-06-22

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