A highly sensitive glucose sensor based on a gold nanoparticles/polyaniline/multi-walled carbon nanotubes composite modified glassy carbon electrode,New Journal of Chemistry

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A highly sensitive glucose sensor based on a gold nanoparticles/polyaniline/multi-walled carbon nanotubes composite modified glassy carbon electrode
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-06-21 00:00:00 , DOI: 10.1039/c7nj04327a
Xinping Zeng _{1,

2,

3,

4} , Yazhou Zhang _{2,

3,

4,

5,

6} , Xiling Du _{1,

2,

3,

4} , Yanfei Li _{4,

7,

8,

9} , Wenwei Tang _{2,

3,

4,

5,

6}

Affiliation

An amperometric glucose sensor, PTFE/GOx/AuNPs/PANI/MWCNTs/GCE, was assembled layer-by-layer using multi-wall carbon nanotubes (MWCNTs), polyaniline (PANI), and gold nanoparticles (AuNPs) for electrode surface modification and a fixed glucose oxidase enzyme (GOx) carrier. Methods such as cyclic voltammetry (CV) and chronoamperometry (CA) were used to investigate the performance of the modified materials and the sensor itself. The sensor responded well to glucose, and the enzyme fixed on the sensor experienced direct electron transfer (DET). The redox peak current for GOx exhibited a good linear relationship to the scan rate. The apparent heterogeneous electron transfer rate constant, K, was 5.19 s⁻¹ (n = 2); the sensor reached 95.0% of the maximum stable current in 10 s. Moreover, the linear range for the glucose concentration was 0.0625 mM to 1.19 mM with a sensitivity of 29.17 μA mM⁻¹ cm⁻² and a detection limit of 0.19 μM. The sensor retained 92.0% of its initial activity after 30 days. The average relative standard deviation for the serum sample measurements was 2.3% (n = 3). The recovery rates ranged from 97.3% to 104.1% for various glucose concentrations. The results indicate that the PTFE/GOx/AuNPs/PANI/MWCNTs/GCE sensor can measure the glucose concentration in human serum and holds potential for future clinical applications.

中文翻译：

基于金纳米颗粒/聚苯胺/多壁碳纳米管复合修饰玻碳电极的高灵敏度葡萄糖传感器

使用多壁碳纳米管（MWCNT），聚苯胺（PANI）和金纳米颗粒（AuNPs）逐层组装安培型葡萄糖传感器PTFE / GOx / AuNPs / PANI / MWCNTs / GCE，用于电极表面修饰和固定的葡萄糖氧化酶（GOx）载体。循环伏安法（CV）和计时电流法（CA）等方法用于研究改性材料和传感器本身的性能。传感器对葡萄糖反应良好，固定在传感器上的酶经历了直接电子转移（DET）。GOx的氧化还原峰值电流与扫描速率表现出良好的线性关系。表观异质电子传递速率常数K为5.19 s ^-1（n= 2）; 传感器在10 s内达到最大稳定电流的95.0％。此外，葡萄糖浓度的线性范围为0.0625mM至1.19mM，灵敏度为29.17μAmM ^-1 cm ^-2，检测极限为0.19μM。30天后，该传感器保留了其初始活动的92.0％。血清样品测量的平均相对标准偏差为2.3％（n = 3）。对于各种葡萄糖浓度，回收率在97.3％至104.1％的范围内。结果表明，PTFE / GOx / AuNPs / PANI / MWCNTs / GCE传感器可以测量人血清中的葡萄糖浓度，具有未来临床应用的潜力。

更新日期：2018-06-21

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