Background

Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported.

Objectives

To assess the prevalence and incidence of PsA in patients with psoriasis.

Methods

Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of PsA in patients with psoriasis. A proportion meta-analysis was performed to calculate the pooled proportion estimates of PsA in patients with psoriasis.

Results

A total of 266 studies examining 976,408 patients with psoriasis were included. Overall, the pooled proportion (95% confidence interval [CI]) of PsA among patients with psoriasis was 19.7% (95% CI, 18.5%-20.9%). In children and adolescents (<18 years of age), the pooled prevalence was 3.3% (95% CI, 2.1%-4.9%). The PsA prevalence was 22.7% (95% CI, 20.6%-25.0%) in European patients with psoriasis, 21.5% (95% CI, 15.4%-28.2%) in South American patients with psoriasis, 19.5% (95% CI, 17.1%-22.1%) in North American patients with psoriasis, 15.5% (95% CI, 0.009%-51.5%) in African patients with psoriasis, and 14.0% (95% CI, 95% CI, 11.7%-16.3%) in Asian patients with psoriasis. The prevalence of PsA was 23.8% (95% CI, 20.1%-27.6%) in studies in which the Classification Criteria for Psoriatic Arthritis were applied. The incidence of PsA among patients with psoriasis ranged from 0.27 to 2.7 per 100 person-years.

Limitations

Between-study heterogeneity may have affected the estimates.

Conclusions

We found that 1 in 4 patients with psoriasis have PsA. With the growing recognition of the Classification Criteria for Psoriatic Arthritis, more homogenous and comparable prevalence estimates are expected to be reported.

中文翻译：

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银屑病患者的银屑病关节炎患病率：观察和临床研究的系统评价和荟萃分析

背景

据报道，牛皮癣患者中银屑病关节炎（PsA）的广泛流行估计。

目标

评估牛皮癣患者中PsA的患病率和发生率。

方法

两位作者独立搜索了3个数据库，以研究牛皮癣患者中PsA的患病率或发生率。进行了比例荟萃分析，以计算银屑病患者中PsA的合并比例估计值。

结果

总共266项研究检查了976,408例牛皮癣患者。总体而言，牛皮癣患者中PsA的合并比例（95％置信区间[CI]）为19.7％（95％CI，18.5％-20.9％）。在儿童和青少年（<18岁）中，合并患病率为3.3％（95％CI，2.1％-4.9％）。欧洲牛皮癣患者的PsA患病率为22.7％（95％CI，20.6％-25.0％），南美南美牛皮癣患者为21.5％（95％CI，15.4％-28.2％），19.5％（95％CI，北美银屑病患者为17.1％-22.1％），非洲银屑病患者为15.5％（95％CI，0.009％-51.5％）和14.0％（95％CI，95％CI，11.7％-16.3％）在亚洲牛皮癣患者中。在应用银屑病关节炎分类标准的研究中，PsA的患病率为23.8％（95％CI，20.1％-27.6％）。

局限性

研究之间的异质性可能影响了估计。

结论

我们发现四分之一的牛皮癣患者患有PsA。随着对银屑病关节炎分类标准的日益认可，预计将报告更加同质和可比的患病率估计值。