Background

Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non–small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma.

Objective

We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF.

Methods

We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples.

Results

In the overall study period, 55 of 58 MF samples (94.8 %) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P < .0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD.

Limitations

We did not conduct a validation study for MF cases in other institutions.

Conclusions

CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF.

中文翻译：

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CADM1是早期真菌病真菌的诊断标志物：58例多中心研究

背景

蕈样真菌病（MF）是最常见的皮肤T细胞淋巴瘤。早期MF斑块通常类似于炎症性皮肤病（ISD），包括牛皮癣和特应性皮炎。细胞粘附分子1基因（CADM1）最初被鉴定为人类非小细胞肺癌的抑癌基因，据报道已成为成人T细胞白血病/淋巴瘤的诊断标记。

客观的

我们研究了CADM1在MF肿瘤细胞中的表达，尤其是在早期阶段，并评估了其作为MF诊断标志物的有用性。

方法

我们使用免疫组织化学染色进行了回顾性研究，并证实了CADM1在MF中的表达。此外，我们比较了显微解剖的MF样品和ISD样品中CADM1信使RNA的表达。

结果

在整个研究期间，58个MF样本中有55个（94.8％）的CADM1染色呈阳性。50个ISD样品均未显示阳性反应（P  <.0001）。我们在MF患者的皮内淋巴细胞中发现了CADM1信使RNA表达，而在ISD患者的皮内淋巴细胞中却没有发现。

局限性

我们没有在其他机构对MF案例进行验证研究。

结论

CADM1阳性细胞可以在早期以较少的浸润细胞进行鉴定，并且可用作早期MF的诊断标记。