Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A–Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond.

尽管最近爆发了寨卡病毒（ZIKV），但仍然没有批准的治疗方法，而且早期化合物可能距离批准还有很多年。本文对ZIKV药物发现工作的最新进展进行了全面的AZ评估，重点介绍了药物重新定位和计算指导的化合物，包括发现的病毒和宿主细胞抑制剂。还描述和讨论了有希望的ZIKV分子靶标以及属于宿主细胞的靶标，这是ZIKV药物发现的新机会。所有这些知识不仅对推进对抗寨卡病毒和其他黄病毒的斗争至关重要，而且还有助于我们为下一次将要应对的新出现的病毒爆发做好准备。