In this article, some recent trends and developments in ambient desorption/ionization mass spectrometry (ADI-MS) are reviewed, with a special focus on quantitative analyses with direct, open-air sampling. Accurate quantification with ADI-MS is still not routinely performed, but this aspect is considered of utmost importance for the advancement of the field. In fact, several research groups are devoted to the development of novel and optimized ADI-MS approaches. Some key trends include novel sample introduction strategies for improved reproducibility, tailored sample preparation protocols for removing the matrix and matrix effects, and multimode ionization sources. In addition, there is significant interest in quantitative mass spectrometry imaging.

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在本文中，回顾了环境解吸/电离质谱（ADI-MS）的一些最新趋势和发展，特别侧重于直接，露天采样的定量分析。ADI-MS的精确定量分析仍未常规进行，但对于该领域的发展而言，这一方面被认为是极为重要的。实际上，有几个研究小组致力于开发新颖且经过优化的ADI-MS方法。一些关键趋势包括用于提高重现性的新颖样品引入策略，用于去除基质和基质效应的量身定制的样品制备方案以及多模式电离源。此外，人们对定量质谱成像也非常感兴趣。

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