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Reduced Graphene Oxide Nanocomposite Modified Electrodes for Sensitive Detection of Ciprofloxacin
Electroanalysis ( IF 2.7 ) Pub Date : 2018-06-20 , DOI: 10.1002/elan.201700738
Tien Song Hiep Pham 1 , Peter J. Mahon 1 , Guosong Lai 2 , Aimin Yu 1, 2
Affiliation  

The synthesis of novel nanocomposites with great sensing enhancement has played an important role in analytical chemistry, especially in the electrochemical detection of drug molecules. In this work, we report a wet chemical method for the preparation of a gold nanoparticle coated β‐cyclodextrin functionalized reduced graphene oxide nanocomposite. A number of different analytical techniques including ultraviolet‐visible spectroscopy, fourier transform infrared spectroscopy, scanning electron microscope and energy dispersive X‐ray spectroscopy were employed to characterize the as‐synthesized nanocomposite. With excellent electrocatalytic properties and high supramolecular recognition ability, the as‐synthesized nanocomposite was used to modify a glassy carbon electrode surface for the sensitive determination of ciprofloxacin using voltammetric technique. The current response of ciprofloxacin on the nanocomposite modified electrode was greatly enhanced compared to that on the bare and other modified electrodes. Using differential pulse voltammetry, the oxidation peak currents increased linearly with the ciprofloxacin concentrations in the range between 0.01 to 120 μM with a detection limit of 2.7 nM. The electrochemical testing results showed good stability and reproducibility. Therefore, the nanocomposite could be a potential candidate for the development of electrochemical sensors for sensitive and selective determination of ciprofloxacin or similar drugs in the future.

中文翻译:

还原氧化石墨烯纳米复合修饰电极用于环丙沙星的灵敏检测

具有显着增强感测能力的新型纳米复合材料的合成在分析化学中,尤其是在药物分子的电化学检测中,发挥了重要作用。在这项工作中,我们报告了一种湿化学方法,用于制备金纳米颗粒包覆的β-环糊精功能化的还原氧化石墨烯纳米复合材料。多种不同的分析技术包括紫外可见光谱,傅立叶变换红外光谱,扫描电子显微镜和能量色散X射线光谱被用来表征合成后的纳米复合材料。具有出色的电催化性能和超分子识别能力,所合成的纳米复合材料用于修饰玻碳电极表面,用于使用伏安法灵敏地测定环丙沙星。相比于裸电极和其他修饰电极,环丙沙星在纳米复合修饰电极上的电流响应大大增强。使用差分脉冲伏安法,氧化峰电流随环丙沙星浓度在0.01至120μM之间线性增加,检测极限为2.7 nM。电化学测试结果显示出良好的稳定性和可重复性。因此,该纳米复合材料可能是将来开发用于敏感和选择性测定环丙沙星或类似药物的电化学传感器的潜在候选者。相比于裸电极和其他修饰电极,环丙沙星在纳米复合修饰电极上的电流响应大大增强。使用差分脉冲伏安法,氧化峰电流随环丙沙星浓度在0.01至120μM之间线性增加,检测极限为2.7 nM。电化学测试结果显示出良好的稳定性和可重复性。因此,该纳米复合材料可能是将来开发用于敏感和选择性测定环丙沙星或类似药物的电化学传感器的潜在候选者。相比于裸电极和其他修饰电极,环丙沙星在纳米复合修饰电极上的电流响应大大增强。使用差分脉冲伏安法,氧化峰电流随环丙沙星浓度在0.01至120μM之间线性增加,检测极限为2.7 nM。电化学测试结果显示出良好的稳定性和可重复性。因此,该纳米复合材料可能是将来开发用于敏感和选择性测定环丙沙星或类似药物的电化学传感器的潜在候选者。氧化峰电流随环丙沙星浓度在0.01至120μM之间线性增加,检出限为2.7 nM。电化学测试结果显示出良好的稳定性和可重复性。因此,该纳米复合材料可能是将来开发用于敏感和选择性测定环丙沙星或类似药物的电化学传感器的潜在候选者。氧化峰电流随环丙沙星浓度在0.01至120μM之间线性增加,检出限为2.7 nM。电化学测试结果显示出良好的稳定性和可重复性。因此,该纳米复合材料可能是将来开发用于敏感和选择性测定环丙沙星或类似药物的电化学传感器的潜在候选者。
更新日期:2018-06-20
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