Ultra-Performance Liquid Chromatography/electrospray ionization mass spectrometry was used for the trace level determination of isopropyl methylphosphonofluoridate (Sarin, GB) and (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) after extraction from various foods. A method utilizing normal phase silica gel was developed for the sample preparation and extraction of VX and GB from food. The extraction efficiencies of the normal phase silica gel method for VX was compared to those of other commercial solid phase extraction media and was found to be comparable. Sarin was found to be incompatible with both the mixed mode cation exchange (MCX) sorbents and QuEChERS methods that are commercially available but was successful with the normal phase silica gel method. The linear range of quantitation for VX was 0.1–330 ng/mL and for GB was 20–1200 ng/mL. The average recoveries of VX and GB from the various food matrices along with the corresponding relative standard deviations (RSDs) are reported.

中文翻译：

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使用正相硅胶和超高效液相色谱-飞行时间质谱（UPLC–TOF–MS）对食品中的沙丁鱼和VX进行痕量分析

使用超高效液相色谱/电喷雾电离质谱法测定痕量水平的异丙基甲基膦酰氟（Sarin，GB）和（O-乙基S从各种食品中提取出来的-[[2-（二异丙基氨基）乙基]甲基硫代磷酸酯（VX）。开发了一种利用正相硅胶的方法来制备样品并从食品中提取VX和GB。将正相硅胶法对VX的萃取效率与其他市售固相萃取介质的萃取效率进行了比较，发现具有可比性。已发现Sarin与混合模式阳离子交换（MCX）吸附剂和QuEChERS方法均不兼容，后者既可通过商业途径获得，也可通过正相硅胶方法获得成功。VX的定量线性范围是0.1–330 ng / mL，GB的线性范围是20–1200 ng / mL。报告了各种食品基质中VX和GB的平均回收率以及相应的相对标准偏差（RSD）。