Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids,Journal of Fluorine Chemistry

当前位置： X-MOL 学术 › J. Fluorine Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of pentafluorosulfanyl (SF5) containing aromatic amino acids
Journal of Fluorine Chemistry ( IF 1.7 ) Pub Date : 2018-06-18 , DOI: 10.1016/j.jfluchem.2018.06.006
Lucas Grigolato ₁ , William D G Brittain ₁ , Alex S Hudson ₁ , Maria M Czyzewska ₁ , Steven L Cobb ₁

Affiliation

Herein, a series of aromatic pentafluorosulfanyl (SF₅) containing amino acids are reported. A Negishi cross-coupling strategy utilising a catalyst system of Pd(dba)₂ and SPhos afforded the aforementioned SF₅ amino acids in yields between 32% and 42%. Two dipeptides utilising both the amine and carboxylic functionalities of the synthesised SF₅ containing amino acids were prepared, demonstrating their compatibility with common amide/peptide coupling reagents and strategies.

中文翻译：