A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy†,Journal of Materials Chemistry B

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A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-20 00:00:00 , DOI: 10.1039/c8tb00989a
Lin Huang _{1,

2,

3,

4,

5} , Jia Liu _{6,

7,

8,

9,

10} , Fan Gao _{5,

10,

11,

12} , Qian Cheng _{5,

10,

11,

12} , Bo Lu _{1,

2,

3,

4,

5} , Hua Zheng _{1,

2,

3,

4,

5} , Haixing Xu _{1,

2,

3,

4,

5} , Peihu Xu _{1,

2,

3,

4,

5} , Xianzheng Zhang _{5,

10,

11,

12} , Xuan Zeng _{5,

10,

11,

12}

Affiliation

In this study, a novel drug delivery system (HMSNs-SS-HA) based on hollow mesoporous silica nanoparticles (HMSNs) was developed for delivering anticancer drugs (e.g., doxorubicin (DOX)) to targeted tumour cells by using disulfide bonds as redox-sensitive linkers and hyaluronic acid (HA) molecules as both capping and targeting agents. Well-dispersed HMSNs were synthesized with a dimension of around 100 nm. Detailed physical characterization further demonstrated that HMSNs-SS-HA has been successfully constructed. The in vitro drug release experiments displayed the enzyme and redox dual-responsive and sustained drug release properties of DOX loaded HMSNs-SS-HA. Additionally, a series of biological evaluations indicated that these DOX loaded HMSNs-SS-HA could accurately target murine mammary carcinoma (4T1) cells to induce cell apoptosis in vitro and suppress tumour growth in vivo. These results demonstrated that DOX loaded HMSNs-SS-HA was suitable as a potential and efficient drug delivery nanosystem for cancer therapy.

中文翻译：

基于空心中孔二氧化硅纳米粒子的双重响应透明质酸靶向药物递送系统，用于癌症治疗†

在这项研究中，开发了一种基于空心中孔二氧化硅纳米粒子（HMSNs）的新型药物递送系统（HMSNs-SS-HA），用于通过使用二硫键作为氧化还原酶将抗癌药物（例如，阿霉素（DOX））递送至目标肿瘤细胞敏感的接头和透明质酸（HA）分子作为封端剂和靶向剂。合成了分散良好的HMSN，其尺寸约为100 nm。详细的物理特征进一步证明了HMSNs-SS-HA已成功构建。在体外药物释放实验显示了载有DOX的HMSNs-SS-HA的酶和氧化还原双重响应和持续药物释放特性。此外，一系列生物学评估表明，这些装有DOX的HMSNs-SS-HA可以准确靶向小鼠乳腺癌细胞（4T1），从而在体外诱导细胞凋亡并在体内抑制肿瘤生长。这些结果表明，载有DOX的HMSNs-SS-HA适合作为潜在且有效的癌症治疗药物纳米系统。

更新日期：2018-06-20

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