Relaxation dynamics of saturated and unsaturated oriented lipid bilayers†,Soft Matter

当前位置： X-MOL 学术 › Soft Matter › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Relaxation dynamics of saturated and unsaturated oriented lipid bilayers†
Soft Matter ( IF 2.9 ) Pub Date : 2018-06-19 00:00:00 , DOI: 10.1039/c7sm01720k
Hirsh Nanda ₁ , Victoria García Sakai , Sheila Khodadadi , Madhu Sudan Tyagi , Edwin J Schwalbach , Joseph E Curtis

Affiliation

We present experimental measurements and analysis of the dynamics and the phase behaviour of saturated DMPC and unsaturated DOPC oriented multi-lamellar bilayers. Elastic and inelastic neutron scattering were used to directly probe the dynamical processes of these membrane systems on time and length scales relevant to the internal and localized motion of lipid monomers. Mobility in this regime can be informative in elucidating the local interactions responsible for material properties of these fluid lipid systems. DMPC and DOPC are structurally similar in terms of their membrane hydrophobic thickness; however, they exhibit different mechanical properties in terms of both elastic compressibility and bending moduli. The analyses suggest that the constraint imposed by the double bonds in DOPC acyl chains restricts atomic motion in both liquid and gel phases compared to DMPC. We discuss applications of molecular dynamics to further elucidate the atomic details of the dynamical processes. Such an understanding may suggest how membrane properties can be tuned using a variety of different lipid species.

中文翻译：

饱和和不饱和定向脂质双层的弛豫动力学†

我们对饱和 DMPC 和不饱和 DOPC 取向的多层双层的动力学和相行为进行了实验测量和分析。弹性和非弹性中子散射被用来直接探测这些膜系统在与脂质单体的内部和局部运动相关的时间和长度尺度上的动力学过程。这种状态下的迁移率可以为阐明负责这些流体脂质系统的材料特性的局部相互作用提供信息。 DMPC和DOPC在膜疏水厚度方面结构相似；然而，它们在弹性压缩率和弯曲模量方面表现出不同的机械性能。分析表明，与 DMPC 相比，DOPC 酰基链中的双键所施加的约束限制了液相和凝胶相中的原子运动。我们讨论分子动力学的应用，以进一步阐明动力学过程的原子细节。这种理解可能表明如何使用各种不同的脂质种类来调节膜特性。

更新日期：2018-06-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11