4‐Dimethylaminopyridine‐Catalyzed Regioselective [3+2] Cycloaddition of Isatin‐Derived Morita−Baylis−Hillman Adducts with Azo Esters: A Simple Protocol to Access 3‐Spiropyrazole‐2‐oxindoles,Advanced Synthesis & Catalysis

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4‐Dimethylaminopyridine‐Catalyzed Regioselective [3+2] Cycloaddition of Isatin‐Derived Morita−Baylis−Hillman Adducts with Azo Esters: A Simple Protocol to Access 3‐Spiropyrazole‐2‐oxindoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-07-04 , DOI: 10.1002/adsc.201800552
Yue Ren ₁ , Ling-Guo Meng ₁ , Tao Peng ₁ , Lijuan Zhu ₁ , Lei Wang _{1,

2}

Affiliation

An efficient and regioselective 4‐dimethylaminopyridine catalyzed [3+2] cycloaddition of isatin‐derived Morita−Baylis−Hillman adducts with azo esters was developed for the construction of 3‐spiropyrazole‐2‐oxindoles. This protocol generated the desired spiropyrazoles in good to excellent yields with good functional group compatibility under mild reaction conditions.

中文翻译：

含偶氮酯的Isatin衍生的Morita-Baylis-Hillman加合物的4-二甲基氨基吡啶催化的区域选择性[3 + 2]环加成反应：访问3-Spiropyrazole-2-oxindoles的简单协议

开发了一种高效且区域选择性的4-二甲基氨基吡啶催化的3-2环糊精衍生的靛蓝衍生的森田-贝利斯-希尔曼加合物与偶氮酯的环加成反应，用于3-螺并吡唑-2-氧吲哚的构建。该方案在温和的反应条件下以良好的收率和良好的官能团相容性生成了所需的螺吡唑。

更新日期：2018-07-04

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