Functional Enzyme Mimics for Oxidative Halogenation Reactions that Combat Biofilm Formation,Advanced Materials

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Functional Enzyme Mimics for Oxidative Halogenation Reactions that Combat Biofilm Formation
Advanced Materials ( IF 27.4 ) Pub Date : 2018-06-19 , DOI: 10.1002/adma.201707073
Karoline Herget ₁ , Hajo Frerichs ₁ , Felix Pfitzner ₁ , Muhammad Nawaz Tahir ₁ , Wolfgang Tremel ₁

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Transition‐metal oxide nanoparticles and molecular coordination compounds are highlighted as functional mimics of halogenating enzymes. These enzymes are involved in halometabolite biosynthesis. Their activity is based upon the formation of hypohalous acids from halides and hydrogen peroxide or oxygen, which form bioactive secondary metabolites of microbial origin with strong antibacterial and antifungal activities in follow‐up reactions. Therefore, enzyme mimics and halogenating enzymes may be valuable tools to combat biofilm formation. Here, halogenating enzyme models are briefly described, enzyme mimics are classified according to their catalytic functions, and current knowledge about the settlement chemistry and adhesion of fouling organisms is summarized. Enzyme mimics with the highest potential are showcased. They may find application in antifouling coatings, indoor and outdoor paints, polymer membranes for water desalination, or in aquacultures, but also on surfaces for food packaging, door handles, hand rails, push buttons, keyboards, and other elements made of plastic where biofilms are present. The use of natural compounds, formed in situ with nontoxic and abundant metal oxide enzyme mimics, represents a novel and efficient “green” strategy to emulate and utilize a natural defense system for preventing bacterial colonization and biofilm growth.

中文翻译：

用于对抗生物膜形成的氧化卤化反应的功能性酶模拟物

过渡金属氧化物纳米颗粒和分子配位化合物被认为是卤化酶的功能模拟物。这些酶参与卤代代谢物的生物合成。它们的活性基于卤化物和过氧化氢或氧气形成次卤酸，次卤酸形成微生物来源的生物活性次级代谢产物，在后续反应中具有很强的抗菌和抗真菌活性。因此，酶模拟物和卤化酶可能是对抗生物膜形成的有价值的工具。在这里，简要描述了卤化酶模型，根据其催化功能对酶模拟物进行了分类，并总结了有关沉降化学和污垢生物粘附的最新知识。展示了具有最高潜力的酶模拟物。它们可以应用于防污涂料、室内和室外油漆、用于海水淡化的聚合物膜或水产养殖，还可以应用于食品包装、门把手、扶手、按钮、键盘和其他由生物膜制成的塑料元件的表面。存在。使用无毒且丰富的金属氧化物酶模拟物原位形成的天然化合物代表了一种新颖且有效的“绿色”策略，可以模拟和利用自然防御系统来防止细菌定植和生物膜生长。

更新日期：2018-06-19

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