Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives,Angewandte Chemie International Edition

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Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-13 , DOI: 10.1002/anie.201806238
Pernille H. Poulsen ₁ , Yang Li ₁ , Vibeke H. Lauridsen ₁ , Danny K. B. Jørgensen ₁ , Teresa A. Palazzo ₁ , Marta Meazza ₁ , Karl Anker Jørgensen ₁

Affiliation

A novel reaction that provides chiral allenes by amino catalytic activation of either aldehydes or α,β‐unsaturated aldehydes for reaction with alkynyl‐substituted enones is presented. The reaction forms a variety of trisubstituted allenes in high yields and with excellent stereoselectivities. The utility of the reaction concept is demonstrated by the synthesis of chiral furan derivatives in high yields and stereoselectivities.

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