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Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-13 , DOI: 10.1002/anie.201806238
Pernille H. Poulsen 1 , Yang Li 1 , Vibeke H. Lauridsen 1 , Danny K. B. Jørgensen 1 , Teresa A. Palazzo 1 , Marta Meazza 1 , Karl Anker Jørgensen 1
Affiliation  

A novel reaction that provides chiral allenes by amino catalytic activation of either aldehydes or α,β‐unsaturated aldehydes for reaction with alkynyl‐substituted enones is presented. The reaction forms a variety of trisubstituted allenes in high yields and with excellent stereoselectivities. The utility of the reaction concept is demonstrated by the synthesis of chiral furan derivatives in high yields and stereoselectivities.

中文翻译:

手性三取代的烯和手性呋喃衍生物的有机催化形成

提出了一种新的反应,该反应通过醛或α,β-不饱和醛的氨基催化活化来与炔基取代的烯酮反应,从而提供手性异戊烯。该反应以高产率和优异的立体选择性形成各种三取代的烯丙基。通过高产率和立体选择性合成手性呋喃衍生物证明了该反应概念的实用性。
更新日期:2018-07-13
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