Copper(II)‐Catalyzed Selective Para Amination of Arylamine with Pyrazole by C−H Functionalization,ChemCatChem

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Copper(II)‐Catalyzed Selective Para Amination of Arylamine with Pyrazole by C−H Functionalization
ChemCatChem ( IF 3.8 ) Pub Date : 2018-07-06 , DOI: 10.1002/cctc.201800328
Jun Xu ₁ , Kui Du ₁ , Jiabin Shen ₁ , Chao Shen ₁ , Kejie Chai ₁ , Pengfei Zhang ₁

Affiliation

A coordinating activation strategy for selective para amination of arylamine with pyrazole is developed. Various substrates are compatible, giving the corresponding products in moderate to good yields. This strategy provides a practical solution for the efficient synthesis of arylamine‐containing pharmacophores from simple starting materials. A single electron transfer mechanism is suggested for this reaction.

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