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Cancer‐Cell Imaging Using Copper‐Doped Zeolite Imidazole Framework‐8 Nanocrystals Exhibiting Oxidative Catalytic Activity
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-08-05 , DOI: 10.1002/asia.201800749 Changjoon Keum 1 , Sangwoo Park 2 , Sang-Yup Lee 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-08-05 , DOI: 10.1002/asia.201800749 Changjoon Keum 1 , Sangwoo Park 2 , Sang-Yup Lee 1
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Copper‐doped zeolite imidazole framework‐8 (Cu/ZIF‐8) was prepared and its peroxidase‐like oxidative catalytic activity was examined with a demonstration of its applicability for cancer‐cell imaging. Through simple solution chemistry at room temperature, Cu/ZIF‐8 nanocrystals were produced that catalytically oxidized an organic substrate of o‐phenylenediamine in the presence of H2O2. In a similar manner to peroxidase, the Cu/ZIF‐8 nanocrystals oxidized the substrate through a ping‐pong mechanism with an activation energy of 59.2 kJ mol−1. The doped Cu atoms functioned as active sites in which the active Cu intermediates were expected to be generated during the catalysis, whereas the undoped ZIF‐8 did not show any oxidative activity. Cu/ZIF‐8 nanocrystals exhibited low cell toxicity and displayed catalytic activity through interaction with H2O2 among various reactive oxygen species in a cancer cell. This oxidative activity in vitro allowed cancer‐cell imaging by exploiting the photoluminescence emitted from the oxidized product of o‐phenylenediamine, which was insignificant in the absence of the Cu/ZIF‐8 nanocrystals. The results of this study suggest that the Cu/ZIF‐8 nanocrystal is a promising catalyst for the analysis of the microbiological systems.
中文翻译：
使用具有氧化催化活性的铜掺杂沸石咪唑框架-8纳米晶体进行癌细胞成像
制备了铜掺杂的咪唑骨架-8（Cu / ZIF-8），并检查了其过氧化物酶样的氧化催化活性，并证明了其在癌细胞成像中的适用性。通过在室温下简单的溶液化学反应，制得了Cu / ZIF-8纳米晶体，该晶体在H 2 O 2存在下催化氧化邻苯二胺的有机底物。与过氧化物酶类似，Cu / ZIF-8纳米晶体通过乒乓机制氧化了底物，活化能为59.2 kJ mol -1。掺杂的铜原子充当了活性位点，预计在催化过程中会生成活性铜中间体，而未掺杂的ZIF-8则没有任何氧化活性。Cu / ZIF-8纳米晶体具有低细胞毒性，并通过与癌细胞中各种活性氧之间的H 2 O 2相互作用而显示出催化活性。这种体外的氧化活性通过利用邻苯二胺的氧化产物发出的光致发光而使癌细胞成像，而在没有Cu / ZIF-8纳米晶体的情况下这是微不足道的。这项研究的结果表明，Cu / ZIF-8纳米晶体是用于分析微生物系统的有前途的催化剂。
更新日期：2018-08-05
中文翻译：
使用具有氧化催化活性的铜掺杂沸石咪唑框架-8纳米晶体进行癌细胞成像
制备了铜掺杂的咪唑骨架-8（Cu / ZIF-8），并检查了其过氧化物酶样的氧化催化活性，并证明了其在癌细胞成像中的适用性。通过在室温下简单的溶液化学反应，制得了Cu / ZIF-8纳米晶体，该晶体在H 2 O 2存在下催化氧化邻苯二胺的有机底物。与过氧化物酶类似，Cu / ZIF-8纳米晶体通过乒乓机制氧化了底物，活化能为59.2 kJ mol -1。掺杂的铜原子充当了活性位点，预计在催化过程中会生成活性铜中间体，而未掺杂的ZIF-8则没有任何氧化活性。Cu / ZIF-8纳米晶体具有低细胞毒性，并通过与癌细胞中各种活性氧之间的H 2 O 2相互作用而显示出催化活性。这种体外的氧化活性通过利用邻苯二胺的氧化产物发出的光致发光而使癌细胞成像，而在没有Cu / ZIF-8纳米晶体的情况下这是微不足道的。这项研究的结果表明，Cu / ZIF-8纳米晶体是用于分析微生物系统的有前途的催化剂。
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