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Developing a Self‐Healing Supramolecular Nucleoside Hydrogel Based on Guanosine and Isoguanosine
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-07-04 , DOI: 10.1002/asia.201800788 Fan Tang 1 , Hui Feng 1, 2 , Yuqi Du 1 , Yandi Xiao 1 , Hongxia Dan 1 , Hang Zhao 1 , Qianming Chen 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-07-04 , DOI: 10.1002/asia.201800788 Fan Tang 1 , Hui Feng 1, 2 , Yuqi Du 1 , Yandi Xiao 1 , Hongxia Dan 1 , Hang Zhao 1 , Qianming Chen 1
Affiliation
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Recently, supramolecular hydrogels have attracted increasing interest owing to their tunable stability and inherent biocompatibility. However, only few studies have been reported in the literature on self‐healing supramolecular nucleoside hydrogels, compared to self‐healing polymer hydrogels. In this work, we successfully developed a self‐healing supramolecular nucleoside hydrogel obtained by simply mixing equimolar amounts of guanosine (G) and isoguanosine (isoG) in the presence of K+. The gelation properties have been studied systematically by comparing different alkali metal ions as well as mixtures with different ratios of G and isoG. To this end, rheological and phase diagram experiments demonstrated that the co‐gel not only possessed good self‐healing properties and short recovery time (only 20 seconds) but also could be formed at very low concentrations of K+. Furthermore, nuclear magnetic resonance (NMR), powder X‐ray diffraction (PXRD), and circular dichroism (CD) spectroscopy suggested that possible G2isoG2‐quartet structures occurred in this self‐healing supramolecular nucleoside hydrogel. This co‐gel, to some extent, addressed the problem of isoguanosine gels for the applications in vivo, which showed the potential to be a new type of drug delivery system for biomedical applications in the future.
中文翻译：
开发基于鸟苷和异鸟苷的自修复超分子核苷水凝胶
近年来，超分子水凝胶由于其可调的稳定性和固有的生物相容性而引起了越来越多的兴趣。然而，与自修复聚合物水凝胶相比，文献中报道的自修复超分子核苷水凝胶的研究很少。在这项工作中，我们成功地开发了一种自修复超分子核苷水凝胶，通过在 K +存在下简单混合等摩尔量的鸟苷（G）和异鸟苷（isoG）而获得。通过比较不同碱金属离子以及不同G和isoG比例的混合物，系统地研究了其凝胶性能。为此，流变学和相图实验表明，共凝胶不仅具有良好的自修复性能和较短的恢复时间（仅20秒），而且可以在极低浓度的K +下形成。此外，核磁共振（NMR）、粉末X射线衍射（PXRD）和圆二色性（CD）光谱表明，这种自修复超分子核苷水凝胶中可能存在G 2 isoG 2 -四重体结构。这种共凝胶在一定程度上解决了异鸟苷凝胶在体内应用的问题，表明其有可能成为未来生物医学应用的新型药物递送系统。
更新日期：2018-07-04
中文翻译：
开发基于鸟苷和异鸟苷的自修复超分子核苷水凝胶
近年来，超分子水凝胶由于其可调的稳定性和固有的生物相容性而引起了越来越多的兴趣。然而，与自修复聚合物水凝胶相比，文献中报道的自修复超分子核苷水凝胶的研究很少。在这项工作中，我们成功地开发了一种自修复超分子核苷水凝胶，通过在 K +存在下简单混合等摩尔量的鸟苷（G）和异鸟苷（isoG）而获得。通过比较不同碱金属离子以及不同G和isoG比例的混合物，系统地研究了其凝胶性能。为此，流变学和相图实验表明，共凝胶不仅具有良好的自修复性能和较短的恢复时间（仅20秒），而且可以在极低浓度的K +下形成。此外，核磁共振（NMR）、粉末X射线衍射（PXRD）和圆二色性（CD）光谱表明，这种自修复超分子核苷水凝胶中可能存在G 2 isoG 2 -四重体结构。这种共凝胶在一定程度上解决了异鸟苷凝胶在体内应用的问题，表明其有可能成为未来生物医学应用的新型药物递送系统。
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