Recently, supramolecular hydrogels have attracted increasing interest owing to their tunable stability and inherent biocompatibility. However, only few studies have been reported in the literature on self‐healing supramolecular nucleoside hydrogels, compared to self‐healing polymer hydrogels. In this work, we successfully developed a self‐healing supramolecular nucleoside hydrogel obtained by simply mixing equimolar amounts of guanosine (G) and isoguanosine (isoG) in the presence of K⁺. The gelation properties have been studied systematically by comparing different alkali metal ions as well as mixtures with different ratios of G and isoG. To this end, rheological and phase diagram experiments demonstrated that the co‐gel not only possessed good self‐healing properties and short recovery time (only 20 seconds) but also could be formed at very low concentrations of K⁺. Furthermore, nuclear magnetic resonance (NMR), powder X‐ray diffraction (PXRD), and circular dichroism (CD) spectroscopy suggested that possible G₂isoG₂‐quartet structures occurred in this self‐healing supramolecular nucleoside hydrogel. This co‐gel, to some extent, addressed the problem of isoguanosine gels for the applications in vivo, which showed the potential to be a new type of drug delivery system for biomedical applications in the future.

中文翻译：

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基于鸟苷和异鸟苷开发自愈超分子核苷水凝胶

近来，超分子水凝胶由于其可调的稳定性和固有的生物相容性而引起了越来越多的关注。但是，与自修复的聚合物水凝胶相比，文献中只有很少的关于自修复的超分子核苷水凝胶的研究报道。在这项工作中，我们成功开发了一种自我修复的超分子核苷水凝胶，只需在K ⁺存在下将等摩尔量的鸟苷（G）和异鸟苷（isoG）混合即可获得。通过比较不同的碱金属离子以及具有不同比例的G和isoG的混合物，系统地研究了胶凝特性。为此，流变学和相图实验表明，共凝胶不仅具有良好的自愈特性和较短的恢复时间（仅20秒），而且还可以在非常低的K ⁺浓度下形成。此外，核磁共振（NMR），粉末X射线衍射（PXRD）和圆二色性（CD）光谱表明可能存在G ₂ isoG ₂四重结构出现在这种自我修复的超分子核苷水凝胶中。这种共凝胶在某种程度上解决了在体内应用的异鸟苷凝胶的问题，这表明将来有可能成为新型的生物医学应用药物递送系统。