There is an increasing demand for biocompatible materials in biomedical applications. Herein, we report a modified α-helical decapeptide segment from the cardiac troponin C, which self-assembles into fibers with a secondary β-sheet structure. These fibers cross-link via a novel supramolecular threading mechanism which results in an atypical stiff hydrogel (G′ ≈ 13 kPa). In this work, we provide a first insight into the understanding of such remarkable cross-linking mechanism, which will aid in the development of new biomaterials with unique properties.

中文翻译：

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肽水凝胶原纤维的超分子穿线

在生物医学应用中对生物相容性材料的需求不断增长。在此，我们报道了来自心肌肌钙蛋白C的修饰的α-螺旋十肽段，该段自组装成具有次级β-折叠结构的纤维。这些纤维通过一种新颖的超分子穿线机构交联，其结果在非典型的硬凝胶（ģ '≈13千帕）。在这项工作中，我们提供了对这种出色的交联机制的理解的初步见解，这将有助于开发具有独特性能的新型生物材料。