Dietary methionine restriction regulated energy and protein homeostasis by improving thyroid function in high fat diet mice†,Food & Function

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Dietary methionine restriction regulated energy and protein homeostasis by improving thyroid function in high fat diet mice†
Food & Function ( IF 5.1 ) Pub Date : 2018-06-19 00:00:00 , DOI: 10.1039/c8fo00685g
Yuhui Yang ₁ , Jiahong Zhang , Guoqing Wu , Jin Sun , Yanan Wang , Haitao Guo , Yonghui Shi , Xiangrong Cheng , Xue Tang , Guowei Le

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Methionine-restricted diets (MRD) show an integrated series of beneficial health effects, including improving insulin sensitivity, limiting fat deposition, and decreasing oxidative stress, and inflammation responses. We aimed to explore the systemic responses to a MRD in mice fed with a high fat (HFD) and clarify the possible mechanism. Mice were fed with a control diet (0.86% methionine + 4% fat, CON), HFD (0.86% methionine + 20% fat), or MRD (0.17% methionine + 20% fat) for 22 consecutive weeks. HFD-fed mice showed widespread systemic metabolic disorders and thyroid dysfunction. A MRD significantly increased energy expenditure (e.g. fatty acid oxidation, glycolysis, and tricarboxylic acid cycle metabolism), regulated protein homeostasis, improved gut microbiota functions, prevented thyroid dysfunction, increased plasma thyroxine and triiodothyronine levels, decreased plasma thyroid stimulating hormone levels, increased type 2 deiodinase (DIO2) activity, and up-regulated mRNA and protein expression levels of DIO2 and thyroid hormone receptor α1 in the skeletal muscle. These results suggest that a MRD can improve the metabolic disorders induced by a HFD, and especially regulate energy and protein homeostasis likely through improved thyroid function. Thus, reducing methionine intake (e.g. through a vegan diet) may improve metabolic health in animals and humans.

中文翻译：

饮食蛋氨酸限制通过改善高脂肪饮食小鼠的甲状腺功能来调节能量和蛋白质稳态†

蛋氨酸限制饮食 (MRD) 显示出一系列有益的健康影响，包括提高胰岛素敏感性、限制脂肪沉积、减少氧化应激和炎症反应。我们的目的是探索高脂肪 (HFD) 喂养小鼠对 MRD 的全身反应，并阐明可能的机制。小鼠连续 22 周饲喂对照饮食（0.86% 蛋氨酸 + 4% 脂肪，CON）、HFD（0.86% 蛋氨酸 + 20% 脂肪）或 MRD（0.17% 蛋氨酸 + 20% 脂肪）。高脂饮食喂养的小鼠表现出广泛的全身代谢紊乱和甲状腺功能障碍。 MRD显着增加能量消耗（例如脂肪酸氧化、糖酵解和三羧酸循环代谢），调节蛋白质稳态，改善肠道微生物群功能，预防甲状腺功能障碍，增加血浆甲状腺素和三碘甲状腺原氨酸水平，降低血浆促甲状腺激素水平，增加类型2 脱碘酶 (DIO2) 活性，并上调骨骼肌中 DIO2 和甲状腺激素受体 α1 的 mRNA 和蛋白表达水平。这些结果表明，MRD 可以改善 HFD 引起的代谢紊乱，特别是可能通过改善甲状腺功能来调节能量和蛋白质稳态。因此，减少蛋氨酸摄入量（例如通过纯素饮食）可以改善动物和人类的代谢健康。

更新日期：2018-06-19

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