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Paranemic Crossover DNA: There and Back Again.
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-06-18 , DOI: 10.1021/acs.chemrev.8b00207 Xing Wang 1 , Arun Richard Chandrasekaran 2 , Zhiyong Shen 3 , Yoel P Ohayon 4 , Tong Wang 4 , Megan E Kizer 1 , Ruojie Sha 4 , Chengde Mao 5 , Hao Yan 6 , Xiaoping Zhang 4 , Shiping Liao 4 , Baoquan Ding 4 , Banani Chakraborty 4 , Natasha Jonoska 7 , Dong Niu 4 , Hongzhou Gu 4 , Jie Chao 4 , Xiang Gao 4 , Yuhang Li 4 , Tanashaya Ciengshin 4 , Nadrian C Seeman 4
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-06-18 , DOI: 10.1021/acs.chemrev.8b00207 Xing Wang 1 , Arun Richard Chandrasekaran 2 , Zhiyong Shen 3 , Yoel P Ohayon 4 , Tong Wang 4 , Megan E Kizer 1 , Ruojie Sha 4 , Chengde Mao 5 , Hao Yan 6 , Xiaoping Zhang 4 , Shiping Liao 4 , Baoquan Ding 4 , Banani Chakraborty 4 , Natasha Jonoska 7 , Dong Niu 4 , Hongzhou Gu 4 , Jie Chao 4 , Xiang Gao 4 , Yuhang Li 4 , Tanashaya Ciengshin 4 , Nadrian C Seeman 4
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Over the past 35 years, DNA has been used to produce various nanometer-scale constructs, nanomechanical devices, and walkers. Construction of complex DNA nanostructures relies on the creation of rigid DNA motifs. Paranemic crossover (PX) DNA is one such motif that has played many roles in DNA nanotechnology. Specifically, PX cohesion has been used to connect topologically closed molecules, to assemble a three-dimensional object, and to create two-dimensional DNA crystals. Additionally, a sequence-dependent nanodevice based on conformational change between PX and its topoisomer, JX2, has been used in robust nanoscale assembly lines, as a key component in a DNA transducer, and to dictate polymer assembly. Furthermore, the PX motif has recently found a new role directly in basic biology, by possibly serving as the molecular structure for double-stranded DNA homology recognition, a prominent feature of molecular biology and essential for many crucial biological processes. This review discusses the many attributes and usages of PX-DNA-its design, characteristics, applications, and potential biological relevance-and aims to accelerate the understanding of PX-DNA motif in its many roles and manifestations.
中文翻译：
副传染性交叉DNA：在那里又回来了。
在过去的35年中，DNA被用于生产各种纳米级的结构，纳米机械装置和助步器。复杂的DNA纳米结构的构建依赖于刚性DNA图案的产生。副交叉（PX）DNA是一种这样的基序，在DNA纳米技术中发挥了许多作用。具体而言，PX内聚力已用于连接拓扑封闭的分子，组装三维物体和创建二维DNA晶体。此外，基于PX及其拓扑异构体JX2之间构象变化的依赖序列的纳米器件已被用于坚固的纳米级装配线中，作为DNA换能器中的关键组件，并决定了聚合物的装配。此外，PX主题最近在基础生物学中直接发现了新角色，通过可能用作双链DNA同源性识别的分子结构，这是分子生物学的显着特征，并且对于许多关键的生物学过程都是必不可少的。这篇综述讨论了PX-DNA的许多属性和用途-它的设计，特征，应用和潜在的生物学相关性-旨在加深对PX-DNA母体在其许多作用和表现形式中的了解。
更新日期：2018-06-18
中文翻译：
副传染性交叉DNA：在那里又回来了。
在过去的35年中，DNA被用于生产各种纳米级的结构，纳米机械装置和助步器。复杂的DNA纳米结构的构建依赖于刚性DNA图案的产生。副交叉（PX）DNA是一种这样的基序，在DNA纳米技术中发挥了许多作用。具体而言，PX内聚力已用于连接拓扑封闭的分子，组装三维物体和创建二维DNA晶体。此外，基于PX及其拓扑异构体JX2之间构象变化的依赖序列的纳米器件已被用于坚固的纳米级装配线中，作为DNA换能器中的关键组件，并决定了聚合物的装配。此外，PX主题最近在基础生物学中直接发现了新角色，通过可能用作双链DNA同源性识别的分子结构，这是分子生物学的显着特征，并且对于许多关键的生物学过程都是必不可少的。这篇综述讨论了PX-DNA的许多属性和用途-它的设计，特征，应用和潜在的生物学相关性-旨在加深对PX-DNA母体在其许多作用和表现形式中的了解。
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