Cyclosporine A-Loaded Nanocarriers for Topical Treatment of Murine Experimental Autoimmune Uveoretinitis,Molecular Pharmaceutics

当前位置： X-MOL 学术 › Mol. Pharmaceutics › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cyclosporine A-Loaded Nanocarriers for Topical Treatment of Murine Experimental Autoimmune Uveoretinitis
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-06-18 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00014
Maren Kasper ₁ , Doris Gabriel ₂ , Michael Möller ₃ , Dirk Bauer ₁ , Lena Wildschütz ₁ , Herve Courthion ₂ , Marta Rodriguez-Aller ₃ , Martin Busch ₁ , Michael R.R. Böhm ₄ , Karin Loser , Solon Thanos , Robert Gurny _{2,

3} , Arnd Heiligenhaus _{1,

5}

Affiliation

In the present study, tissue distribution and the therapeutic effect of topically applied cyclosporine A (CsA)-loaded methoxy-poly(ethylene-glycol)-hexyl substituted poly(lactic acid) (mPEGhexPLA) nanocarriers (ApidSOL) on experimental autoimmune uveitis (EAU) were investigated. The CsA-loaded mPEGhexPLA nanocarrier was tolerated well locally and showed no signs of immediate toxicity after repeated topical application in mice with EAU. Upon unilateral CsA treatment, CsA accumulated predominantly in the corneal and sclera-choroidal tissue of the treated eye and in lymph nodes (LN). This regimen reduced EAU severity in treated eyes compared to PBS-treated controls. This improvement was accompanied by reduced T-cell count, T-cell proliferation, and IL-2 secretion of cells from ipsilateral LN. In conclusion, topical treatment with CsA-loaded mPEGhexPLA nanocarriers significantly improves the outcome of EAU.

中文翻译：

载有环孢菌素A的纳米载体局部治疗小鼠实验性自身免疫性葡萄膜视网膜炎

在本研究中，局部分布的环孢素A（CsA）负载的甲氧基-聚（乙二醇）-己基取代的聚乳酸（mPEGhexPLA）纳米载体（ApidSOL）的组织分布和对实验性自身免疫性葡萄膜炎（EAU）的治疗作用）进行了调查。负载CsA的mPEGhexPLA纳米载体在局部耐受良好，在EAU小鼠中反复局部应用后未显示出立即毒性的迹象。单方面CsA治疗后，CsA主要在被治疗眼的角膜和巩膜脉络膜组织以及淋巴结（LN）中积累。与PBS处理的对照组相比，该方案可降低治疗组眼睛的EAU严重程度。这种改善伴随着同侧LN的T细胞计数减少，T细胞增殖和IL-2分泌减少。综上所述，

更新日期：2018-06-18

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11