Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

中文翻译：

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来自白蚁巢的药用真菌 Xylaria fimbriata 的异戊二烯酚醚

从白蚁巢来源的药用真菌 Xylaria fimbriata YMJ491 的发酵液中分离出七种新的异戊二烯酚醚，即菌醚 A-G (1-7)。它们的结构由光谱数据分析确定，并与报道的结构进行比较。评价了100 μM浓度的所有分离物对脂多糖（LPS）诱导的小鼠巨噬细胞RAW 264.7细胞中一氧化氮（NO）产生的抑制作用，它们均表现出Emax值范围内的NO产生抑制活性。从 4.6 ± 2.0% 到 49.7 ± 0.5%，没有明显的细胞毒性。此外，这七种化合物不会改变 C57BL/6J 小鼠分离的完整胸主动脉环中去氧肾上腺素诱导的血管收缩，