Hyperbranched polymers (HPs) have widely been used for drug delivery owing to their highly branched topology, which endows the HPs with a large amount of intramolecular cavities for drug encapsulation and terminal groups for drug conjugation. Additionally, one‐pot, large‐scale preparations enable the easy fabrication of HPs for biomedical applications. This review provides an overview of the synthesis of HPs and their application for drug delivery. First, we introduce a diversity of methods for the synthesis of HPs with controllable topologies. Subsequently, we discuss drug encapsulation and drug conjugation by using HPs. Finally, we highlight the use of HPs with controllable topologies for promising drug delivery.

中文翻译：

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具有可控拓扑结构的超支化聚合物，可用于药物输送

超支化聚合物（HPs）由于其高度支化的拓扑结构而被广泛用于药物输送，这使HPs具有大量的分子内腔用于药物封装和末端基团用于药物偶联。此外，一锅大规模制备使生物医学应用中的HP易于制造。这篇综述概述了HP的合成及其在药物递送中的应用。首先，我们介绍了具有可控拓扑的多种HP合成方法。随后，我们讨论了使用HPs进行药物封装和药物结合。最后，我们重点介绍具有可控拓扑结构的HP在有希望的药物输送中的使用。