Protocatechuic acid is used extensively in pharmacological and related industries which can also be obtained by fermentation. Reactive separation by means of reactive extractant is a favourable alternative to recover carboxylic acids from the aqueous dilute streams and the fermentation broth. In this paper, the reactive separation of protocatechuic acid were performed by D2EHPA (Di-(2-ethylhexyl) phosphoric acid) and TOA (tri-n-octyl amine) dissolved in MIBK (Methyl isobutyl ketone) at 298 K. Distribution coefficients, degree of extraction, complexation constants and loading ratio were estimated. The equilibrium for protocatechuic acid-extractant-diluent system was represented using Langmuir model, mass action law and relative basicity model. Results obtained from model were found to be close to experimental data. TOA was found more effective than D2EHPA for the recovery of protocatechuic acid having 5.39 as maximum distribution coefficient and 84.36% efficiency at 0.01 mol L⁻¹ and 1.1437 mol L⁻¹ concentration of protocatechuic acid and TOA respectively.

原儿茶酸广泛用于药理学和相关工业，也可以通过发酵获得。借助于反应性萃取剂的反应性分离是从稀水流和发酵液中回收羧酸的有利选择。本文采用D2EHPA（二-（2-乙基己基）磷酸）和TOA（三正辛胺）溶解在MIBK（甲基异丁酮）中于298 K进行反应分离。估计提取度，络合常数和负载率。用Langmuir模型，质量作用定律和相对碱度模型表示原儿茶酸-萃取剂-稀释剂系统的平衡。发现从模型获得的结果接近于实验数据。原儿茶酸和TOA的浓度分别为^-1和1.1437 mol L ^-1。