Vitamin B₁₂ import is all about timing

Vitamin B₁₂ import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3

Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

中文翻译：

---

维生素B 12的进口与时机有关

维生素B _12的进口与时机有关

维生素B <sub> 12 </ sub>的进口与时机有关，在线发布：2018年6月18日; doi：10.1038 / s41589-018-0087-3

单分子技术与分子动力学模拟相结合，可以直观地观察ABC进口系统BtuCD-F在运输周期中构象均一性的高水平，并揭示了导致维生素B12结合，运输的独特构象态出乎意料的紧密结合然后释放。