A simple micellar electrokinetic chromatography (MEKC), using cetyltrimethyl ammonium bromide (CTAB) as micelles, for the determination of ciprofloxacin (CIP), enrofloxacin (ENR), norfloxacin (NOR) and ofloxacin (OFL) residues in surface water was developed. Peak Master was used for predicting amounts of analyte ionic forms to reduce numbers of tedious experiments in optimizing the analyte capacity factors. A baseline separation (R_s > 2.8) of the analytes was achieved in 7 min using 15 mM sodium dihydrogen phosphate (pH 6.0) containing 3 mM CTAB and a capillary with an effective length of 56.0 cm. A negative polarity voltage of 20 kV was used to enable the migration of the cationic micelles toward the detection site. The method shows good linearity in a range of 5 and 20 μg mL⁻¹ and precision (%RSD < 6.45). Percent recoveries of the method were in a range of 65.1–88.7%. The limits of detection and quantitation were in the ranges of 1–2 and 3–5 μg mL⁻¹, respectively. Two steps sample clean-up and preconcentration of surface water samples by hydrophilic-lipophilic balance and fluoroquinolone-molecularly imprinted polymer were advantageous for removal of humic acids and enabling the detection of fluoroquinolone residues in the samples. Finally, the method was applied for fluoroquinolone residues analysis of surface water in Thailand.

建立了一种以十六烷基三甲基溴化铵（CTAB）为胶束的简单胶束电动色谱（MEKC），用于测定地表水中的环丙沙星（CIP），恩诺沙星（ENR），诺氟沙星（NOR）和氧氟沙星（OFL）残留物。Peak Master用于预测分析物离子形式的数量，以减少优化分析物容量因子时的繁琐实验。 使用含有3 mM CTAB的15 mM磷酸二氢钠（pH 6.0）和有效长度为56.0 cm的毛细管，可在7分钟内实现分析物的基线分离（R _s > 2.8）。使用20 kV的负极性电压使阳离子胶束向检测部位迁移。该方法在5到20μgmL ^-1的范围内显示出良好的线性和精度（％RSD <6.45）。该方法的回收率在65.1–88.7％之间。检测和定量限分别在1-2和3-5μgmL ^-1范围内。通过亲水亲脂平衡和氟喹诺酮分子印迹聚合物分两步进行样品净化和预浓缩地表水样品，对于去除腐殖酸和检测样品中的氟喹诺酮残留物非常有利。最后，该方法用于泰国地表水中氟喹诺酮残留量分析。