Electrochemical strategies for C–H functionalization and C–N bond formation,Chemical Society Reviews

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Electrochemical strategies for C–H functionalization and C–N bond formation
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-06-18 00:00:00 , DOI: 10.1039/c7cs00619e
Markus D. Kärkäs _{1,

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Affiliation

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–nitrogen bond formation are typically conducted at elevated temperatures, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of challenging carbon–carbon and carbon–heteroatom bonds. Here, electrosynthesis has proven to be an environmentally benign, highly effective and versatile platform for achieving a wide range of nonclassical bond disconnections via generation of radical intermediates under mild reaction conditions. This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon–hydrogen functionalization and carbon–nitrogen bond formation strategies. Emphasis is placed on methodology development and mechanistic insight and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.

中文翻译：

C–H功能化和C–N键形成的电化学策略

进行碳氢官能化和形成碳氮键的常规方法通常在高温下进行，并且依赖于昂贵的催化剂以及化学计量的，甚至是有毒的氧化剂的使用。在这方面，最近电化学合成被认为是构建具有挑战性的碳-碳和碳-杂原子键的一种可持续且可扩展的策略。在这里，电合成已被证明是实现广泛的非经典键断开的环境无害，高效的通用平台，通过在温和的反应条件下生成自由基中间体。这篇综述概述了使用阳极电化学方法来加速碳氢官能化和碳氮键形成策略的发展。重点放在方法学的发展和机理的洞察力上，旨在为电合成领域的未来合成应用提供灵感。

更新日期：2018-06-18

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