Semi-volatile organic compounds (SVOCs) are used extensively in consumer and personal care products; electronics; furniture; and building materials and are detected in most indoor environments. As a result, human exposure to mixtures of SVOCs is wide-spread. However, very few studies have measured biomarkers of exposure to multiple SVOC classes, and exposure determinants have not been thoroughly explored, particularly for young children. In this study, we investigated biomarkers of exposure to SVOCs among children (age 3–6 years), who may experience higher exposures and be more susceptible to adverse health outcomes than other age groups. We enrolled 203 participants in the Toddlers Exposure to SVOCs in Indoor Environments (TESIE) study (181 provided urine samples and 90 provided serum samples).We quantified 44 biomarkers of exposure to phthalates, organophosphate esters (OPEs), parabens, phenols, antibacterial agents and per- and polyfluoroalkyl substances (PFASs); we detected 29 of the 44 biomarkers in >95% of samples, and many biomarkers were detected at higher median concentrations than those previously reported in the U.S. general population. Demographic characteristics were associated with differences in concentrations. In general, non-Hispanic white race and higher maternal education were associated with lower concentrations, even after adjusting for other potential confounding variables. Our results suggest that outdoor temperature at the time of biospecimen collection may be a particularly important and under-evaluated predictor of biomarker concentrations; statistically significant relationships were observed between 10 biomarkers and outdoor temperature at the time of collection. A complex correlation structure was also observed among the biomarkers assessed. By and large, statistically significant correlations between biomarkers of exposure to phthalates, parabens, phenols, and OPEs were positive. Conversely, although PFASs were positively correlated with one another, they tended to be negatively correlated with other biomarkers where significant associations were observed. Taken together, our results provide evidence that the assessments of SVOC-associated health impacts should focus on chemical mixtures.

半挥发性有机化合物（SVOC）广泛用于消费和个人护理产品中；电子产品; 家具; 和建筑材料，并在大多数室内环境中被检测到。结果，人类广泛接触到SVOC混合物。但是，很少有研究测量暴露于多种SVOC类别的生物标志物，并且尚未全面探索暴露决定因素，尤其是对于幼儿。在这项研究中，我们调查了3至6岁儿童中SVOC暴露的生物标志物，与其他年龄组相比，这些儿童可能遭受更高的暴露，并且更容易受到不良健康后果的影响。我们招收203名参与者幼儿暴露于室内环境半挥发性有机化合物（TESIE）研究（181个提供尿样和90个提供的血清样品）。我们定量曝光的44种生物标志物，以邻苯二甲酸酯，有机磷酸酯的酯（OPE），对羟基苯甲酸酯，酚，抗菌剂以及全氟和多氟烷基物质（PFAS）；我们在超过95％的样本中检测到了44种生物标志物中的29种，而且检测到的许多生物标志物的中值浓度都比以前在美国普通人群中报道的浓度高。人口统计学特征与浓度差异有关。通常，即使在调整了其他潜在的混杂变量之后，非西班牙裔的白人种族和较高的孕产妇教育水平也与较低的集中度相关。我们的结果表明，收集生物样本时的室外温度可能是生物标记物浓度的一个特别重要且被低估的指标。收集时观察到10种生物标记物与室外温度之间的统计显着性关系。在所评估的生物标记物之间还观察到复杂的相关结构。总体而言，邻苯二甲酸盐，对羟基苯甲酸酯，酚和OPEs的生物标志物之间的生物统计学相关性呈正相关。相反，尽管PFAS之间存在正相关，但它们与其他生物标记之间却存在显着负相关。综上所述，我们的结果提供了证据，即与SVOC相关的健康影响的评估应集中在化学混合物上。它们倾向于与观察到显着关联的其他生物标志物负相关。综上所述，我们的结果提供了证据，即与SVOC相关的健康影响的评估应集中在化学混合物上。它们倾向于与观察到显着关联的其他生物标志物负相关。综上所述，我们的结果提供了证据，即与SVOC相关的健康影响的评估应集中在化学混合物上。