Abstract During the last decade, translational research on biodegradable metallic materials has shown the feasibility of these novel materials for use in the fields of cardiology and orthopedics. Implants prepared with biodegradable metals are significantly stronger than their polymer counterparts, and there is now convincing evidence demonstrating that these materials fully biodegrade in vivo, thus reducing the need for secondary surgery. Clinical trials of such novel materials show significant potential, with the prospect of a paradigm shift in the way musculoskeletal and cardiovascular conditions are treated. This work provides an overview of the rapidly advancing technology of biodegradable metals, as well as defining some challenges in the application of these new biodegradable materials in the medical field.

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可生物降解金属的临床转化现状与展望

摘要 在过去十年中，可生物降解金属材料的转化研究表明这些新型材料在心脏病学和骨科领域的应用的可行性。用可生物降解的金属制备的植入物比聚合物对应物强得多，现在有令人信服的证据表明这些材料在体内完全生物降解，从而减少了二次手术的需要。这种新型材料的临床试验显示出巨大的潜力，有望改变肌肉骨骼和心血管疾病的治疗方式。这项工作概述了快速发展的可生物降解金属技术，并定义了这些新的可生物降解材料在医疗领域的应用中的一些挑战。