Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease, and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to increase of IGF-1 plasma levels. The activation of the GH/IGF-1 axis leads to an increase of muscle mass and functional capacity. Ghrelin further acts on inflammation, appetite, and adipogenesis and for this reason was considered an important target to address catabolic conditions. We report the synthesis and properties of an indane based series of ghrelin receptor full agonists; they have been shown to generate a sustained increase of IGF-1 levels in dog and have been thoroughly investigated with respect to their functional activity.

中文翻译：

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基于茚满系列的Ghrelin受体完全激动剂的鉴定和药理作用

恶病质和肌肉消瘦在患有癌症，慢性阻塞性肺疾病和其他慢性疾病的患者中非常普遍。Ghrelin通过Ghrelin受体刺激生长激素分泌，随后导致IGF-1血浆水平升高。GH / IGF-1轴的激活导致肌肉质量和功能能力的增加。Ghrelin进一步作用于炎症，食欲和脂肪形成，因此被认为是解决分解代谢疾病的重要目标。我们报告了基于茚满的一系列ghrelin受体完全激动剂的合成和性质。已显示它们可在犬中产生IGF-1水平的持续增加，并已就其功能活性进行了深入研究。