An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO2 nanosystem for fluorescence imaging-guided efficient photodynamic therapy†,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO2 nanosystem for fluorescence imaging-guided efficient photodynamic therapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-17 00:00:00 , DOI: 10.1039/c8tb00931g
Rong-gui Wang _{1,

2,

3,

4} , Meng-yao Zhao _{1,

2,

3,

4} , Di Deng _{1,

2,

3,

4} , Xin Ye _{1,

2,

3,

4} , Fan Zhang _{1,

2,

3,

4} , Hui Chen _{1,

2,

3,

4} , Ji-lie Kong _{1,

2,

3,

4}

Affiliation

Photodynamic therapy (PDT) has been widely applied in cancer treatment due to minimal invasion, negligible side effects and specific tumor ablation. However, the treatment efficiency has been hindered by hypoxia in solid tumors, hydrophobic photosensitizers and their real time tracking. In this paper, we constructed an intelligent and biocompatible bovine serum albumin (BSA)–Ce6–Si QDs–MnO₂ (BCSM NPs) nanocomplex as a pH/H₂O₂ responsive photosensitizer nanocarrier to modulate tumor hypoxia for fluorescence imaging-guided efficient PDT. This versatile nanosystem not only enhanced the loading capacity of the photosensitizer and the formation of cytotoxic singlet oxygen (¹O₂) owing to the intelligent production of oxygen catalyzed by MnO₂ from the endogenous H₂O₂, but also performed as a dual functional fluorescence and Magnetic Resonance imaging (MRI) probe. In vivo experiments in nude mice further confirmed that BCSM NPs significantly inhibited the growth of HeLa bearing-tumors compared to free Ce6. The results highlight the great potentail of multifunctional BCSM NPs for in vivo imaging as well as enhancing the photodynamic therapy efficiency.

中文翻译：

一种智能且生物相容的光敏剂共轭硅量子点MnO ₂纳米系统，用于荧光成像引导的高效光动力疗法†

光动力疗法（PDT）由于具有极小的侵袭，可忽略的副作用和特定的肿瘤消融作用而被广泛应用于癌症治疗。但是，实体瘤中的低氧，疏水性光敏剂及其实时跟踪已阻碍了治疗效率。在本文中，我们构建了一种智能且生物相容的牛血清白蛋白（BSA）–Ce6–Si QDs–MnO ₂（BCSM NPs）纳米复合物，作为pH / H ₂ O ₂响应型光敏剂纳米载体，可调节肿瘤缺氧，从而实现荧光成像引导的高效太平洋夏令时。这种多功能的纳米系统不仅增强了光敏剂的负载能力，还增强了细胞毒性单线态氧（¹ O ₂）是由于MnO ₂从内源性H ₂ O ₂催化智能生产氧气，而且还可以用作双重功能的荧光和磁共振成像（MRI）探针。裸鼠体内实验进一步证实，与游离Ce6相比，BCSM NPs显着抑制HeLa荷瘤肿瘤的生长。结果突出了多功能BCSM NP在体内成像以及增强光动力治疗效率方面的巨大潜力。

更新日期：2018-06-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11