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Analysis of Breakthrough Behaviors of Hydrophilic and Hydrophobic Pharmaceuticals in a Novel Clay Composite Adsorbent Column in the Presence and Absence of Biofilm
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2018-06-29 , DOI: 10.1021/acs.iecr.8b00987 Arya Vijayanandan 1 , Ligy Philip 1 , S. Murty Bhallamudi 1
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2018-06-29 , DOI: 10.1021/acs.iecr.8b00987 Arya Vijayanandan 1 , Ligy Philip 1 , S. Murty Bhallamudi 1
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The present study investigated the use of a novel clay composite adsorbent in simultaneous removal of hydrophilic and hydrophobic pharmaceuticals in a fixed bed column. The potential of a biologically active clay composite adsorbent in removing the pharmaceuticals was examined in detail. The mechanism of adsorption was elucidated based on an equilibrium sorption and mass transfer approach. The effects of dispersion, mass transfer zone, empty bed contact time, and an interfering substance such as humic acid on column operation were investigated in detail. It was observed that adsorption was the dominating mechanism of removal in the biologically active adsorbent column, and the amount of biodegradation gradually increased with an increase in contact time. Breakthrough behaviors of pharmaceuticals were numerically simulated using an equilibrium sorption approach as well as a mass transfer approach. Although both the equilibrium sorption model (EQM) and linear driving force (LDF) model predicted breakthrough behaviors satisfactorily, tailing of the breakthrough curve was better predicted by the LDF model. On the basis of the LDF model, surface diffusion coefficients for atenolol, ciprofloxacin, and gemfibrozil were estimated to be 6.5 × 10–4, 9.4 × 10–4, and 1.2 × 10–3 cm/h, respectively.
中文翻译：
有无生物膜的新型粘土复合吸附柱中亲水和疏水药物的突破行为分析
本研究调查了新型粘土复合吸附剂在固定床色谱柱中同时去除亲水性和疏水性药物的用途。详细检查了生物活性粘土复合吸附剂在去除药物方面的潜力。阐明了基于平衡吸附和传质方法的吸附机理。详细研究了分散液，传质区，空床接触时间和干扰物质（如腐殖酸）对色谱柱操作的影响。观察到吸附是生物活性吸附剂柱中去除的主要机理，并且生物降解量随着接触时间的增加而逐渐增加。使用平衡吸附方法和传质方法对药物的突破行为进行了数值模拟。尽管平衡吸附模型（EQM）和线性驱动力（LDF）模型都可以令人满意地预测击穿行为，但是LDF模型可以更好地预测击穿曲线的拖尾。根据LDF模型，阿替洛尔，环丙沙星和吉非贝齐的表面扩散系数估计为6.5×10分别为–4，9.4×10 –4和1.2×10 –3 cm / h。
更新日期：2018-06-30
中文翻译：
有无生物膜的新型粘土复合吸附柱中亲水和疏水药物的突破行为分析
本研究调查了新型粘土复合吸附剂在固定床色谱柱中同时去除亲水性和疏水性药物的用途。详细检查了生物活性粘土复合吸附剂在去除药物方面的潜力。阐明了基于平衡吸附和传质方法的吸附机理。详细研究了分散液，传质区，空床接触时间和干扰物质（如腐殖酸）对色谱柱操作的影响。观察到吸附是生物活性吸附剂柱中去除的主要机理，并且生物降解量随着接触时间的增加而逐渐增加。使用平衡吸附方法和传质方法对药物的突破行为进行了数值模拟。尽管平衡吸附模型（EQM）和线性驱动力（LDF）模型都可以令人满意地预测击穿行为，但是LDF模型可以更好地预测击穿曲线的拖尾。根据LDF模型，阿替洛尔，环丙沙星和吉非贝齐的表面扩散系数估计为6.5×10分别为–4，9.4×10 –4和1.2×10 –3 cm / h。
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