Stimuli-responsive surfaces with switchable bacterial killing and release are new promising candidates for the development of new antibacterial materials. Although such surfaces have been extensively studied and many advances have been achieved, a number of challenges are remained, including the optimization of structure, moderate stimuli, and so forth. In this paper, we developed a new “killing and release” antibacterial surface by combining poly[2-(tert-butylamino) ethyl methacrylate] (polyTA) and poly(3-(dimethyl (4-vinylbenzyl) ammonio) propyl sulfonate) (polyDVBAPS) via mixed brushes system. The bactericidal activity of polyTA and salt-responsive property of polyDVBAPS could be well integrated in this way. Accordingly, the surface showed high bactericidal activity by killing more than 94% attached bacteria of E. coli and S. aureus and excellent release capability by detaching most attached bacteria in response to salt solution. Both bacterial killing effectiveness and release rate were well retained at a high level of more than 90% after four severe killing and release cycles, indicating the high reliability of surface regeneration. This excellent antibacterial potency made the surface capable to be used in many biological applications, particularly in reusable devices.

中文翻译：

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混合聚合物刷对盐有响应的“杀死和释放”抗菌表面

具有可切换的杀灭和释放细菌的刺激反应性表面，是开发新型抗菌材料的新有希望的候选者。尽管已经对这种表面进行了广泛的研究并取得了许多进展，但是仍然存在许多挑战，包括结构的优化，适度的刺激等等。在本文中，我们通过结合聚[2-（叔-甲基丙烯酸-丁氨基氨基乙酯]（polyTA）和聚（3-（二甲基（4-乙烯基苄基）铵）丙基磺酸盐）（polyDVBAPS）。可以很好地整合polyTA的杀菌活性和polyDVBAPS的盐响应性。因此，通过杀死超过94％的附着的大肠杆菌和金黄色葡萄球菌，该表面显示出高杀菌活性。通过响应盐溶液分离大多数附着的细菌，具有出色的释放能力。经过四个严重的杀死和释放循环后，细菌的杀死效率和释放率都保持在90％以上的高水平，这表明表面再生具有很高的可靠性。这种出色的抗菌功效使该表面能够用于许多生物学应用，尤其是可重复使用的设备。