Enhancing the efficacy of photodynamic therapy (PDT) via water-soluble pillar[5]arene-based supramolecular complexes†,Chemical Communications

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Enhancing the efficacy of photodynamic therapy (PDT) via water-soluble pillar[5]arene-based supramolecular complexes†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-16 00:00:00 , DOI: 10.1039/c8cc04275f
Jian Wu _{1,

2,

3,

4,

5} , Jia Tian _{1,

2,

3,

4,

5} , Leilei Rui _{1,

2,

3,

4,

5} , Weian Zhang _{1,

2,

3,

4,

5}

Affiliation

A supramolecular nanovesicle was constructed by complexation between pyrophaeophorbide A (PPhA) and water-soluble pillar[5]arene, and then a biotin–pyridinium targeting agent was introduced to its surface. This nanovesicle exhibited reduced aggregation of PPhA photosensitizers and high targeting ability towards cancer cells, thereby leading to excellent therapeutic efficacy under red light.

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